WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H532856
CAS#: 301648-08-8
Description: UCB35625 is a potent chemokine CKR-1 (CCR1) and CKR-3 (CCR3) receptor antagonist. It inhibits MIP-1α-induced chemotaxis in CKR-1 transfectants (IC50 = 9.57 nM) and eotaxin-induced chemotaxis in CKR-3 transfectants (IC50 = 93.8 nM). UCB 35625 also antagonizes CKR3-mediated entry of HIV-1 isolate 89.6 into NP-2 cells (IC50 = 57 nM).
Hodoodo Cat#: H532856
Name: UCB35625
CAS#: 301648-08-8
Chemical Formula: C29H37Cl2N2O2+
Exact Mass: 515.22
Molecular Weight: 516.530
Elemental Analysis: C, 67.43; H, 7.22; Cl, 13.73; N, 5.42; O, 6.19
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: UCB35625, UCB 35625, UCB-35625
IUPAC/Chemical Name: 1-(cycloheptylmethyl)-4-(2,7-dichloro-9H-xanthene-9-amido)-1-ethylpiperidin-1-ium
InChi Key: ZTXGBIXSMSZDOC-UHFFFAOYSA-O
InChi Code: InChI=1S/C29H36Cl2N2O2/c1-2-33(19-20-7-5-3-4-6-8-20)15-13-23(14-16-33)32-29(34)28-24-17-21(30)9-11-26(24)35-27-12-10-22(31)18-25(27)28/h9-12,17-18,20,23,28H,2-8,13-16,19H2,1H3/p+1
SMILES Code: CC[N+]1(CC2CCCCCC2)CCC(NC(C3C4=C(OC5=C3C=C(Cl)C=C5)C=CC(Cl)=C4)=O)CC1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 516.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Corbisier J, Huszagh A, Galés C, Parmentier M, Springael JY. Partial Agonist and Biased Signaling Properties of the Synthetic Enantiomers J113863/UCB35625 at Chemokine Receptors CCR2 and CCR5. J Biol Chem. 2017 Jan 13;292(2):575-584. doi: 10.1074/jbc.M116.757559. Epub 2016 Nov 28. PubMed PMID: 27895119; PubMed Central PMCID: PMC5241733.