WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H532968
CAS#: 50370-56-4 (free base)
Description: WIN35428 is a novel allosteric modulators of the dopamine transporter (DAT).
Hodoodo Cat#: H532968
Name: WIN35428
CAS#: 50370-56-4 (free base)
Chemical Formula: C16H20FNO2
Exact Mass: 277.15
Molecular Weight: 277.340
Elemental Analysis: C, 69.29; H, 7.27; F, 6.85; N, 5.05; O, 11.54
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Related CAS #: 141899-22-1 (HCl) 50370-56-4 (free base)
Synonym: WIN35428; WIN 35428; WIN-35428; β-CFT; βCFT.
IUPAC/Chemical Name: methyl (1R,2S,3S,5S)-3-(4-fluorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate
InChi Key: QUSLQENMLDRCTO-YJNKXOJESA-N
InChi Code: InChI=1S/C16H20FNO2/c1-18-12-7-8-14(18)15(16(19)20-2)13(9-12)10-3-5-11(17)6-4-10/h3-6,12-15H,7-9H2,1-2H3/t12-,13+,14+,15-/m0/s1
SMILES Code: O=C([C@@H]1[C@@](N2C)([H])CC[C@@]2([H])C[C@@H]1C3=CC=C(F)C=C3)OC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 277.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Sun J, Kouranova E, Cui X, Mach RH, Xu J. Regulation of dopamine presynaptic markers and receptors in the striatum of DJ-1 and Pink1 knockout rats. Neurosci Lett. 2013 Dec 17;557 Pt B:123-8. doi: 10.1016/j.neulet.2013.10.034. Epub 2013 Oct 22. PubMed PMID: 24157858; PubMed Central PMCID: PMC4144334.
2: Rothman RB, Ananthan S, Partilla JS, Saini SK, Moukha-Chafiq O, Pathak V, Baumann MH. Studies of the biogenic amine transporters 15. Identification of novel allosteric dopamine transporter ligands with nanomolar potency. J Pharmacol Exp Ther. 2015 Jun;353(3):529-38. doi: 10.1124/jpet.114.222299. Epub 2015 Mar 18. PubMed PMID: 25788711; PubMed Central PMCID: PMC4429677.