WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H551003
CAS#: 502137-98-6
Description: HLI373 is a water-soluble inhibitor of Hdm2. HLI373 is effective in inducing apoptosis of several tumor cells lines that are sensitive to DNA-damaging agents. HLI373 could serve as a potential lead for developing cancer therapeutics based on inhibition of the ubiquitin ligase activity of Hdm2.
Hodoodo Cat#: H551003
Name: HLI373
CAS#: 502137-98-6
Chemical Formula: C18H23N5O2
Exact Mass: 341.19
Molecular Weight: 341.415
Elemental Analysis: C, 63.32; H, 6.79; N, 20.51; O, 9.37
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Related CAS #: 1782531-99-0(HCl) 502137-98-6
Synonym: HLI373; HLI-373; HLI 373; NSC-373989; NSC 373989; NSC373989.
IUPAC/Chemical Name: 5-[[3-(Dimethylamino)propyl]amino]-3,10-dimethyl-pyrimido[4,5-b]quinoline-2,4(3H,10H)-dione
InChi Key: LNRUPMPQQGPSQT-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H23N5O2/c1-21(2)11-7-10-19-15-12-8-5-6-9-13(12)22(3)16-14(15)17(24)23(4)18(25)20-16/h5-6,8-9,19H,7,10-11H2,1-4H3
SMILES Code: O=C1N=C2N(C)C3=C(C=CC=C3)C(NCCCN(C)C)=C2C(N1C)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 341.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Kitagaki J, Agama KK, Pommier Y, Yang Y, Weissman AM. Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2. Mol Cancer Ther. 2008 Aug;7(8):2445-54. doi: 10.1158/1535-7163.MCT-08-0063. PubMed PMID: 18723490; PubMed Central PMCID: PMC2588467.