WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H584158
CAS#: 2156-27-6
Description: Benproperine is a bioactive molecule that has antineoplastic properties.
Hodoodo Cat#: H584158
Name: Benproperine
CAS#: 2156-27-6
Chemical Formula: C21H27NO
Exact Mass: 309.21
Molecular Weight: 309.450
Elemental Analysis: C, 81.51; H, 8.79; N, 4.53; O, 5.17
Synonym: Benproperine; Bemproperina; Benproperinum; Pirexyl; BRN 1258822; BRN-1258822; BRN1258822
IUPAC/Chemical Name: 1-(2-(2-Benzylphenoxy)-1-methylethyl)piperidine
InChi Key: JTUQXGZRVLWBCR-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H27NO/c1-18(22-14-8-3-9-15-22)17-23-21-13-7-6-12-20(21)16-19-10-4-2-5-11-19/h2,4-7,10-13,18H,3,8-9,14-17H2,1H3
SMILES Code: CC(N1CCCCC1)COC2=CC=CC=C2CC3=CC=CC=C3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 1.0 | 3.23 | |
| PBS (pH:7.2) | 1.0 | 3.23 |
The following data is based on the product molecular weight 309.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Feng S, Liu J, Han X, Fan J. Resonance light scattering study on the interaction of benproperine phosphate with eriochrome blue black R in the presence of sodium dodecylbenzene sulphonate and its analytical application. Luminescence. 2009 Mar-Apr;24(2):67-72. doi: 10.1002/bio.1064. PubMed PMID: 18800357.
2: Li Y, Zhong DF, Chen SW, Maeba I. Identification of some benproperine metabolites in humans and investigation of their antitussive effect. Acta Pharmacol Sin. 2005 Dec;26(12):1519-26. PubMed PMID: 16297353.
3: Li Y, Sun Y, Dong Y, Zhang Y, Zhong D. Identification and quantitative determination of benproperine metabolites in human plasma and urine by liquid chromatography-tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. 2006 Jan 2;830(1):71-80. Epub 2005 Nov 8. PubMed PMID: 16280263.
4: Chen S, Min L, Li Y, Li W, Zhong D, Kong W. Anti-tussive activity of benproperine enantiomers on citric-acid-induced cough in conscious guinea-pigs. J Pharm Pharmacol. 2004 Feb;56(2):277-80. PubMed PMID: 15005888.
5: Du ZM, Huang HH, Chen XY, Zhong DF. [Study on hydroxylated metabolites of benproperine in human urine]. Yao Xue Xue Bao. 2000 Dec;35(12):916-20. Chinese. PubMed PMID: 12567915.
6: Du ZM, Zhong DF, Kang Y, Chen XY. [Enantioselective pharmacokinetics of benproperine in healthy volunteers]. Yao Xue Xue Bao. 2000 Dec;35(12):909-12. Chinese. PubMed PMID: 12567913.
7: Yang XJ, Yang XY. [Determination of benproperine phosphate tablets by high performance liquid chromatography]. Se Pu. 2000 Nov;18(6):566-7. Chinese. PubMed PMID: 12541753.
