WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H527049
CAS#: 1872382-50-7 (TFA)
Description: UNC4219 is a negative control compound for UNC3866 (GLXC-07803) which is a potent antagonist of the methyllysine (Kme) reading function of the Polycomb CBX and CDY families of chromodomains.
Hodoodo Cat#: H527049
Name: UNC-4219 TFA
CAS#: 1872382-50-7 (TFA)
Chemical Formula: C46H69F3N6O10
Exact Mass: 808.51
Molecular Weight: 923.090
Elemental Analysis: C, 59.85; H, 7.53; F, 6.17; N, 9.10; O, 17.33
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 1872382-50-7 (TFA) 1872382-49-4 (free base)
Synonym: UNC 4219; UNC-4219; UNC4219
IUPAC/Chemical Name: methyl N2-N-((4-(tert-butyl)benzoyl)-L-phenylalanyl)-N-methyl-L-alanyl-L-leucyl-N6,N6-diethyl-L-lysyl-L-serinate trifluoroacetic acid
InChi Key: VSMDTYSYZIIMJK-SBXVYEEZSA-N
InChi Code: InChI=1S/C44H68N6O8.C2HF3O2/c1-11-50(12-2)25-17-16-20-34(40(54)48-37(28-51)43(57)58-10)45-41(55)35(26-29(3)4)46-38(52)30(5)49(9)42(56)36(27-31-18-14-13-15-19-31)47-39(53)32-21-23-33(24-22-32)44(6,7)8;3-2(4,5)1(6)7/h13-15,18-19,21-24,29-30,34-37,51H,11-12,16-17,20,25-28H2,1-10H3,(H,45,55)(H,46,52)(H,47,53)(H,48,54);(H,6,7)/t30-,34-,35-,36-,37-;/m0./s1
SMILES Code: OC[C@@H](C(OC)=O)NC([C@H](CCCCN(CC)CC)NC([C@H](CC(C)C)NC([C@H](C)N(C([C@H](CC1=CC=CC=C1)NC(C2=CC=C(C(C)(C)C)C=C2)=O)=O)C)=O)=O)=O.O=C(O)C(F)(F)F
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 923.09 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Stuckey JI, Dickson BM, Cheng N, Liu Y, Norris JL, Cholensky SH, Tempel W, Qin S, Huber KG, Sagum C, Black K, Li F, Huang XP, Roth BL, Baughman BM, Senisterra G, Pattenden SG, Vedadi M, Brown PJ, Bedford MT, Min J, Arrowsmith CH, James LI, Frye SV. A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Nat Chem Biol. 2016 Mar;12(3):180-7. doi: 10.1038/nchembio.2007. Epub 2016 Jan 25. PubMed PMID: 26807715; PubMed Central PMCID: PMC4755828.
