WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H571453
CAS#: 135-14-8
Description: Quinuronium sulfate is a drug that has been used to treat Babesia divergens infections in calves. It did not prevent treated animals from being disease carriers. It also may cause hepatic centrilobular fatty degeneration, but no depletion of hepatic glutathione (GSH).
Hodoodo Cat#: H571453
Name: Quinuronium Sulfate
CAS#: 135-14-8
Chemical Formula: C23H26N4O9S2
Exact Mass: 0.00
Molecular Weight: 566.600
Elemental Analysis: C, 48.76; H, 4.63; N, 9.89; O, 25.41; S, 11.32
This product is not in stock, which may be available by custom synthesis.
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Synonym: Quinuronium sulfate; Acaprin; Pirevan; Zothelone
IUPAC/Chemical Name: 1,1'-Dimethyl-6,6'-ureylenediquinolinium dimethyl bis(sulphate)
InChi Key: BOMUADPKDXMXIH-UHFFFAOYSA-M
InChi Code: InChI=1S/C21H19N4O.2CH4O4S/c1-24-11-3-5-15-13-17(7-9-19(15)24)22-21(26)23-18-8-10-20-16(14-18)6-4-12-25(20)2;2*1-5-6(2,3)4/h3-14H,1-2H3,(H-,22,23,26);2*1H3,(H,2,3,4)/q+1;;/p-1
SMILES Code: O=C(NC1=CC2=CC=C[N+](C)=C2C=C1)NC3=CC4=CC=C[N+](C)=C4C=C3.O=S(OC)([O-])=O.O=S(OC)([O-])=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 566.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Mitema ES, Maribei JM. Quinuronium induced hepatotoxicity in rats. Toxicol Lett. 1985 Jan;24(1):53-8. PubMed PMID: 3975929.
2: Mitema ES. Comparative studies of the effects of quinuronium sulfate and diminazene diaceturate in sheep. Vet Hum Toxicol. 1985 Dec;27(6):539-42. PubMed PMID: 4082473.
3: Mitema ES. Quinuronium levels in ovine plasma as determined by an in vitro/in vivo system with Babesia rodhaini. Arch Int Pharmacodyn Ther. 1985 Jul;276(1):12-6. PubMed PMID: 4051633.
4: Mitema ES, Nafstad I, Frøslie A. Effects of quinuronium sulfate pre-exposure on hepatic excretion of sulfobromophthalein (BSP) as measured by isolated perfused rat liver. Acta Pharmacol Toxicol (Copenh). 1983 Jul;53(1):44-8. PubMed PMID: 6613606.
5: Brockelman CR, Tan-ariya P. Development of an in vitro microtest to assess drug susceptibility of Babesia bovis and Babesia bigemina. J Parasitol. 1991 Dec;77(6):994-7. PubMed PMID: 1779305.
6: Purnell RE, Lewis D, Young ER. Quinuronium sulphate for the treatment of Babesia divergens infections of splenectomised calves. Vet Rec. 1981 Jun 20;108(25):538-9. PubMed PMID: 7269188.
7: Callow LL, McGregor W. Quinuronium sulphate poisoning of cattle. Vet Rec. 1967 Aug 12;81(7):175-6. PubMed PMID: 6050339.
8: Eyre P. Quinuronium sulphate poisoning. Vet Rec. 1966 Dec 24;79(26):862. PubMed PMID: 6009189.
9: Eyre P. Some pharmacodynamic effects of the babesicidal agents quinuronium and amicarbalide. J Pharm Pharmacol. 1967 Aug;19(8):509-19. PubMed PMID: 4382438.
10: Eyre P. Release of tissue histamine by the babesicidal agents quinuronium and amicarbalide. J Pharm Pharmacol. 1966 Jan;18(1):33-7. PubMed PMID: 4380701.
11: Callow LL, McGregor W. Vaccination against Babesia argentina infection in cattle during chemoprophylaxis with a quinuronium compound. Aust Vet J. 1969 Sep;45(9):408-10. PubMed PMID: 5389523.
12: Eyre P. The effects in sheep of quinuronium and amicarbalice and the influence of atropine pyridine 2-aldoxime methiodide (2-PAM). Adrenaline and mepyramine. Vet Rec. 1966 Apr 30;78(18):627-9. PubMed PMID: 4380961.
13: Mitema ES, Nafstad I, Maribei JM. Acute toxicity studies with quinuronium sulfate in laboratory animals and sheep. Toxicol Lett. 1984 Jan;20(1):69-74. PubMed PMID: 6695398.
14: Löhr FK, Otieno PS, Gacanga W. Therapy trial using betamethasone in addition to specific treatment with a diamidine and quinuronium derivate in cattle experimentally infected with Babesia bigemina. Bull Anim Health Prod Afr. 1976 Jun;24(2):199-205. PubMed PMID: 16300142.
15: Eyre P. Effects of quinuronium methylsulphate on voluntary muscle. Br J Pharmacol Chemother. 1968 Mar;32(3):624-34. PubMed PMID: 5641953; PubMed Central PMCID: PMC1570312.
16: Eyre P. The anticholinesterase activity of the babesicidal agents quinuronium and amicarbalide and the influence of pyridine 2-aldoxime methiodide. Res Vet Sci. 1966 Apr;7(2):161-7. PubMed PMID: 4959552.
