WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H465909
CAS#: 5011-34-7 (free base)
Description: Trimetazidine is an inhibitor of NLRP3/GSDMD pathway-mediated pyroptosis for the treatment of dexamethasone-induced muscle atrophy. The mechanism of action of trimetazidine involves its effect on cellular energy metabolism, specifically the metabolism of fatty acids and glucose. Trimetazidine works by inhibiting a specific enzyme called long-chain 3-ketoacyl-CoA thiolase, which is involved in the beta-oxidation process of fatty acids. By blocking this enzyme, trimetazidine reduces the oxidation of fatty acids and promotes the oxidation of glucose instead. Glucose oxidation requires less oxygen consumption compared to the beta-oxidation of fatty acids.
Hodoodo Cat#: H465909
Name: Trimetazidine free base
CAS#: 5011-34-7 (free base)
Chemical Formula: C14H22N2O3
Exact Mass: 266.16
Molecular Weight: 266.341
Elemental Analysis: C, 63.13; H, 8.33; N, 10.52; O, 18.02
Related CAS #: 13171-25-0 (HCl) 5011-34-7 (free base)
Synonym: Trimetazidine; TMZ; Trimetazidine free base;
IUPAC/Chemical Name: 1-(2,3,4-trimethoxybenzyl)piperazine
InChi Key: UHWVSEOVJBQKBE-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H22N2O3/c1-17-12-5-4-11(13(18-2)14(12)19-3)10-16-8-6-15-7-9-16/h4-5,15H,6-10H2,1-3H3
SMILES Code: COC1=CC=C(C(OC)=C1OC)CN2CCNCC2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: Trimetazidine (TMZ) is a medication used to treat cardiovascular disorders, including angina pectoris , or sudden chest, jaw, or back pain caused by reduced blood flow to the heart. It helps the body metabolize fatty acids, which helps it use oxygen, and allows for more blood flow to the heart. This can help lessen chest pain from blocked blood vessels. TMZ is sold under many brand names and is described as the first cytoprotective anti-ischemic agent developed and marketed by Laboratoires Servier. It's suitable for initial use as monotherapy in patients with angina pectoris, and as adjunctive therapy in those with symptoms not sufficiently controlled by nitrates, beta-blockers, or calcium antagonists .
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The following data is based on the product molecular weight 266.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
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