BMS-250749

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H584230

CAS#: 406913-72-2

Description: BMS-250749 is a fluoroglycosylated fluoroindolocarbazole with antitumor activity.

Chemical Structure

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BMS-250749
CAS# 406913-72-2
Instruction

Theoretical Analysis

Hodoodo Cat#: H584230
Name: BMS-250749
CAS#: 406913-72-2
Chemical Formula: C26H18F3N3O6
Exact Mass: 525.11
Molecular Weight: 525.440
Elemental Analysis: C, 59.43; H, 3.45; F, 10.85; N, 8.00; O, 18.27

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: BMS-250749; BMS250749; BMS 250749

IUPAC/Chemical Name: 5H-Indolo(2,3-a)pyrrolo(3,4-C)carbazole-5,7(6H)-dione, 12-(4-deoxy-4-fluoro-beta-D-glucopyranosyl)-3,9-difluoro-12,13-dihydro-

InChi Key: MUXIBMYSVWHKJF-KLQAUAMZSA-N

InChi Code: InChI=1S/C26H18F3N3O6/c27-8-1-3-12-10(5-8)15-17-18(25(37)31-24(17)36)16-11-6-9(28)2-4-13(11)32(21(16)20(15)30-12)26-23(35)22(34)19(29)14(7-33)38-26/h1-6,14,19,22-23,26,30,33-35H,7H2,(H,31,36,37)/t14-,19-,22+,23-,26-/m1/s1

SMILES Code: O=C1NC(C2=C1C3=C(C4=C2C5=C(N4[C@H]6[C@@H]([C@H]([C@H](F)[C@@H](CO)O6)O)O)C=CC(F)=C5)NC7=C3C=C(F)C=C7)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 525.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Saulnier MG, Balasubramanian BN, Long BH, Frennesson DB, Ruediger E,
Zimmermann K, Eummer JT, St Laurent DR, Stoffan KM, Naidu BN, Mahler M, Beaulieu
F, Bachand C, Lee FY, Fairchild CR, Stadnick LK, Rose WC, Solomon C, Wong H,
Martel A, Wright JJ, Kramer R, Langley DR, Vyas DM. Discovery of a
fluoroindolo[2,3-a]carbazole clinical candidate with broad spectrum antitumor
activity in preclinical tumor models superior to the marketed oncology drug,
CPT-11. J Med Chem. 2005 Apr 7;48(7):2258-61. PubMed PMID: 15801816.

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