WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H584285
CAS#: 99083-11-1
Description: Btg 502 activates sodium channel & inhibits batrachotoxinin A-20-alpha-benzoate binding.
Hodoodo Cat#: H584285
Name: Btg 502
CAS#: 99083-11-1
Chemical Formula: C21H24BrNO
Exact Mass: 385.10
Molecular Weight: 386.333
Elemental Analysis: C, 65.29; H, 6.26; Br, 20.68; N, 3.63; O, 4.14
This product is not in stock, which may be available by custom synthesis.
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Synonym: Btg 502; Btg-502; Btg502
IUPAC/Chemical Name: 2,4-Hexadienamide, 6-(5-bromo-2-naphthalenyl)-N-(1,2-dimethylpropyl)-, (E,E)-
InChi Key: FVMPXCCSVGCCRV-LJIKRCSCSA-N
InChi Code: InChI=1S/C21H24BrNO/c1-15(2)16(3)23-21(24)11-6-4-5-8-17-12-13-19-18(14-17)9-7-10-20(19)22/h4-7,9-16H,8H2,1-3H3,(H,23,24)/b5-4+,11-6+
SMILES Code: O=C(NC(C)C(C)C)/C=C/C=C/CC1=CC=C2C(Br)=CC=CC2=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 386.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Du Y, Khambay B, Dong K. An important role of a pyrethroid-sensing residue F1519 in the action of the N-alkylamide insecticide BTG 502 on the cockroach sodium channel. Insect Biochem Mol Biol. 2011 Jul;41(7):446-50. doi: 10.1016/j.ibmb.2011.03.005. Epub 2011 Mar 21. PubMed PMID: 21426938; PubMed Central PMCID: PMC3118982.
2: Du Y, Garden D, Khambay B, Zhorov BS, Dong K. Batrachotoxin, pyrethroids, and BTG 502 share overlapping binding sites on insect sodium channels. Mol Pharmacol. 2011 Sep;80(3):426-33. doi: 10.1124/mol.111.072504. Epub 2011 Jun 16. PubMed PMID: 21680776; PubMed Central PMCID: PMC3164329.
3: Ottea JA, Payne GT, Bloomquist JR, Soderlund DM. Activation of sodium channels and inhibition of [3H]batrachotoxinin A-20-alpha-benzoate binding by an N-alkylamide neurotoxin. Mol Pharmacol. 1989 Aug;36(2):280-4. PubMed PMID: 2549384.
