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Buquinolate
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WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H584300

CAS#: 5486-03-3

Description: Buquinolate is an anticoccidial agent used in poultry; medicated birds achieve a higher level of egg production & weight gain. Buquinolate does not interfere in immunity formation to coccidia.

Chemical Structure

Buquinolate

CAS# 5486-03-3

Instruction

Theoretical Analysis

Hodoodo Cat#: H584300
Name: Buquinolate
CAS#: 5486-03-3
Chemical Formula: C20H27NO5
Exact Mass: 361.19
Molecular Weight: 361.438
Elemental Analysis: C, 66.46; H, 7.53; N, 3.88; O, 22.13

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 1250	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. Hodoodo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Buquinolate; Bonaid TM; Buchinolatum; Bukhinolyat; Butoril

IUPAC/Chemical Name: 3-Quinolinecarboxylic acid, 4-hydroxy-6,7-bis(2-methylpropoxy)-, ethyl ester

InChi Key: LVVXOXRUTDAKFE-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H27NO5/c1-6-24-20(23)15-9-21-16-8-18(26-11-13(4)5)17(25-10-12(2)3)7-14(16)19(15)22/h7-9,12-13H,6,10-11H2,1-5H3,(H,21,22)

SMILES Code: O=C(C1=C(O)C2=CC(OCC(C)C)=C(OCC(C)C)C=C2N=C1)OCC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 361.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Nakajima T, Hayashi H, Sasamoto T, Kanda M, Kusano T, Matsushima Y, Kanai S, Takeba K, Nagayama T. [Determination of nequinate and buquinolate in livestock products using liquid chromatography-tandem mass spectrometry]. Shokuhin Eiseigaku Zasshi. 2011;52(3):178-82. PubMed PMID: 21720123.

2: Herrett RJ, Williams CW, Klein GM, Heotis JP. The distribution of C14 in the chick following the administration of buquinolate-3-C14. Poult Sci. 1967 May;46(3):755-61. PubMed PMID: 6082025.

3: Edgar SA, Flanagan C. Coccidiostatic effects of buquinolate in poultry. Poult Sci. 1968 Jan;47(1):95-104. PubMed PMID: 5645319.

4: Engle AT, Humphrey RP, Johnson CA. Buquinolate, a new broad spectrum coccidiostat. Poult Sci. 1967 Jul;46(4):810-8. PubMed PMID: 6064475.

5: Leathem WD. Buquinolate and immunization to Eimeria acervulina. Poult Sci. 1973 Jul;52(4):1468-72. PubMed PMID: 4773337.

6: Kohls RE, Engle AT, Butters HE. Effects of continuous buquinolate medication of laying chickens. Avian Dis. 1972 Jul-Sep;16(4):907-14. PubMed PMID: 5079881.

7: Sadler CR, Day EJ, French JE. Efficacy of buquinolate against artificial coccidiosis infection in broiler chickens. Poult Sci. 1968 Nov;47(6):1917-21. PubMed PMID: 5752535.

8: McLoughlin DK. Efficacy of buquinolate against ten strains of Eimeria tenella and the development of a resistant strain. Avian Dis. 1970 Feb;14(1):126-30. PubMed PMID: 5434433.

9: Eckman MK, Kohls RE, Humphrey RP. Relationship of particle size to coccidiostatic efficacy of buquinolate. Avian Dis. 1969 May;13(2):297-308. PubMed PMID: 5816044.

10: Leathem WD, Kohls RE. Acquired immunity of buquinolate-medicated chickens to Eimeria tenella infection. Poult Sci. 1971 Sep;50(5):1492-5. PubMed PMID: 5094394.

11: Leathem WD, Engle AT. Effect of two levels of buquinolate on endogenous development and oocyst suppression of Eimeria tenella. Poult Sci. 1970 Jul;49(4):1109-13. PubMed PMID: 5485480.

12: Onawunmi OA, Todd AC. Suppression and control of experimentally induced procine coccidiosis with chlortetracycline combination, buquinolate, and lincomycin hydrochloride. Am J Vet Res. 1976 Jun;37(6):657-60. PubMed PMID: 937785.

13: Stephens JF, Barnett BD, Butters HE. Effect of buquinolate on growth and egg production of white leghorn pullets. Poult Sci. 1967 Jan;46(1):203-6. PubMed PMID: 6031869.

14: Eckman MK, Humphrey RP, Kohls RE. Efficacy of buquinolate in chickens inoculated with drug-sensitive and drug-tolerant coccidial species. Avian Dis. 1972 May-Jun;16(3):492-500. PubMed PMID: 5038648.

15: Chapman HD. Eimeria tenella in chickens: development of resistance to quinolone anticoccidial drugs. Parasitology. 1975 Aug;71(1):41-9. PubMed PMID: 1058450.

16: Canton JH, van Esch GJ. The short-term toxicity of some feed additives to different freshwater organisms. Bull Environ Contam Toxicol. 1976 Jun;15(6):720-5. PubMed PMID: 938765.

17: Matus JL, Boison JO. A multi-residue method for 17 anticoccidial drugs and ractopamine in animal tissues by liquid chromatography-tandem mass spectrometry and time-of-flight mass spectrometry. Drug Test Anal. 2016 May;8(5-6):465-76. doi: 10.1002/dta.2019. PubMed PMID: 27443201.

18: Mitrovic M, Schildknecht EG. Lasalocid: resistance and cross-resistance studies in Eimeria tenella-infected chicks. Poult Sci. 1975 May;54(3):750-6. PubMed PMID: 1153374.

19: Norton CC, Joyner LP. The development of drug-resistant strains of Eimeria maxima in the laboratory. Parasitology. 1975 Aug;71(1):153-65. PubMed PMID: 1058449.

20: Wang CC. Studies of the mitochondria from Eimeria tenella and inhibition of the electron transport by quinolone coccidiostats. Biochim Biophys Acta. 1975 Aug 11;396(2):210-9. PubMed PMID: 1171697.