WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H571562
CAS#: 59277-89-3 (free)
Description: Acyclovir, a GUANOSINE analog that acts as an antimetabolite. Viruses are especially susceptible. Used especially against herpes. Acyclovir is an antiviral medication. It is primarily used for the treatment of herpes simplex virus infections, chickenpox, and shingles.
Hodoodo Cat#: H571562
Name: Acyclovir
CAS#: 59277-89-3 (free)
Chemical Formula: C8H11N5O3
Exact Mass: 225.09
Molecular Weight: 225.210
Elemental Analysis: C, 42.67; H, 4.92; N, 31.10; O, 21.31
Related CAS #: 69657-51-8 (sodium) 59277-89-3 (free)
Synonym: Activir; ACV; Acycloguanosine; Acyclovir; NSC 645011; NSC-645011; NSC645011, Aciclovir
IUPAC/Chemical Name: 6H-Purin-6-one, 2-amino-1,9-dihydro-9-((2-hydroxyethoxy)methyl)-
InChi Key: MKUXAQIIEYXACX-UHFFFAOYSA-N
InChi Code: InChI=1S/C8H11N5O3/c9-8-11-6-5(7(15)12-8)10-3-13(6)4-16-2-1-14/h3,14H,1-2,4H2,(H3,9,11,12,15)
SMILES Code: O=C1NC(N)=NC2=C1N=CN2COCCO
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | Acyclovir inhibits HSV-1 (IC50 of 0.85 μM), HSV-2 (IC50 of 0.86 μM) and varicella-zoster virus. |
| In vitro activity: | The anti-cyprinid herpesvirus 3 (CyHV-3) activity of acyclovir (ACV) was examined in vitro. ACV (66.67 μM) inhibited a cytopathic effect (CPE) induced by the CyHV-3 virus in the CCB (Common carp brain) by 66% and the KF1 (Koi carp fin 1) by 25%. The viral load measured by the means of TaqMan qPCR was reduced in a range of 67%-93% depending on the analogue, the cell line and the time of incubation. The expression of viral genes (ORF149, ORF3, ORF134 and ORF78) in CCB cells infected with the CyHV-3 was strongly downregulated within the range of 78%-91%. In summary, ACV inhibited CyHV-3 replication in vitro. Reference: J Fish Dis. 2018 Nov;41(11):1709-1718. https://onlinelibrary.wiley.com/doi/10.1111/jfd.12880 |
| In vivo activity: | The combination of acyclovir and dexamethasone (DXMT), but not acyclovir or DXMT alone, could protect against Alzheimer’s disease (AD) causing β-amyloid (Aβ) oligomer-induced spatial cognitive impairments. Moreover, acyclovir and DXMT prevented Aβ oligomer-induced over-activation of microglia and astrocytes, and over-expression of pro-inflammatory cytokines, indicating that anti-AD effects of drug combination might be at least partially via neuroinflammation inhibition and immunomodulation. Furthermore, Aβ oligomer-induced decrease of PSD-95 and increase of pTau expression was prevented by the combination of acyclovir and DXMT, suggesting the involvement of synaptic protective effects of the drug combination. Taken together, these studies indicated that the combination of acyclovir and DXMT might be an alternative therapy for the treatment of AD. Reference: Psychopharmacology (Berl). 2020 Jun;237(6):1851-1860. https://link.springer.com/article/10.1007/s00213-020-05503-1 |
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| PBS (pH 7.2) | 0.2 | 0.89 |
The following data is based on the product molecular weight 225.21 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | 1. Troszok A, Kolek L, Szczygieł J, Wawrzeczko J, Borzym E, Reichert M, Kamińska T, Ostrowski T, Jurecka P, Adamek M, Rakus K, Irnazarow I. Acyclovir inhibits Cyprinid herpesvirus 3 multiplication in vitro. J Fish Dis. 2018 Nov;41(11):1709-1718. doi: 10.1111/jfd.12880. Epub 2018 Aug 24. PMID: 30144085. 2. Hui Z, Zhijun Y, Yushan Y, Liping C, Yiying Z, Difan Z, Chunglit CT, Wei C. The combination of acyclovir and dexamethasone protects against Alzheimer's disease-related cognitive impairments in mice. Psychopharmacology (Berl). 2020 Jun;237(6):1851-1860. doi: 10.1007/s00213-020-05503-1. Epub 2020 Mar 27. PMID: 32221697. |
| In vitro protocol: | 1. Troszok A, Kolek L, Szczygieł J, Wawrzeczko J, Borzym E, Reichert M, Kamińska T, Ostrowski T, Jurecka P, Adamek M, Rakus K, Irnazarow I. Acyclovir inhibits Cyprinid herpesvirus 3 multiplication in vitro. J Fish Dis. 2018 Nov;41(11):1709-1718. doi: 10.1111/jfd.12880. Epub 2018 Aug 24. PMID: 30144085. |
| In vivo protocol: | 1. Hui Z, Zhijun Y, Yushan Y, Liping C, Yiying Z, Difan Z, Chunglit CT, Wei C. The combination of acyclovir and dexamethasone protects against Alzheimer's disease-related cognitive impairments in mice. Psychopharmacology (Berl). 2020 Jun;237(6):1851-1860. doi: 10.1007/s00213-020-05503-1. Epub 2020 Mar 27. PMID: 32221697. |
1: Karim-Nezhad G, Sarkary A, Khorablou Z, Seyed Dorraji P. Synergistic Effect of ZnO Nanoparticles and Carbon Nanotube and Polymeric Film on Electrochemical Oxidation of Acyclovir. Iran J Pharm Res. 2018 Winter;17(1):52-62. PubMed PMID: 29755538.
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10: Benzekri R, Bouslama L, Papetti A, Hammami M, Smaoui A, Limam F. Anti HSV-2 activity of Peganum harmala (L.) and isolation of the active compound. Microb Pathog. 2018 Jan;114:291-298. doi: 10.1016/j.micpath.2017.12.017. Epub 2017 Dec 6. PubMed PMID: 29223449.
11: Casassa EA, Nicol P, Viraben R, Gaudin C, Bulai Livideanu C, Mengelle C, Lamant L, Fortenfant F, Paul C, Konstantinou MP. [Acyclovir-resistant perineal HSV infection revealing chronic lymphoid leukaemia]. Ann Dermatol Venereol. 2018 Mar;145(3):182-186. doi: 10.1016/j.annder.2017.10.013. Epub 2017 Dec 6. French. PubMed PMID: 29221652.
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13: Zinser E, Krawczyk A, Mühl-Zürbes P, Aufderhorst U, Draßner C, Stich L, Zaja M, Strobl S, Steinkasserer A, Heilingloh CS. A new promising candidate to overcome drug resistant herpes simplex virus infections. Antiviral Res. 2018 Jan;149:202-210. doi: 10.1016/j.antiviral.2017.11.012. Epub 2017 Nov 15. PubMed PMID: 29155164.
14: Abdelhameed AS, Bakheit AH, Almutairi FM, AlRabiah H, Kadi AA. Biophysical and In Silico Studies of the Interaction between the Anti-Viral Agents Acyclovir and Penciclovir, and Human Serum Albumin. Molecules. 2017 Nov 5;22(11). pii: E1906. doi: 10.3390/molecules22111906. PubMed PMID: 29113080.
15: Suwannoi P, Chomnawang M, Sarisuta N, Reichl S, Müller-Goymann CC. Development of Acyclovir-Loaded Albumin Nanoparticles and Improvement of Acyclovir Permeation Across Human Corneal Epithelial T Cells. J Ocul Pharmacol Ther. 2017 Dec;33(10):743-752. doi: 10.1089/jop.2017.0057. Epub 2017 Nov 7. PubMed PMID: 29111864.
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20: Bauer D, Keller J, Alt M, Schubert A, Aufderhorst UW, Palapys V, Kasper M, Heilingloh CS, Dittmer U, Laffer B, Eis-Hübinger AM, Verjans GM, Heiligenhaus A, Roggendorf M, Krawczyk A. Antibody-based immunotherapy of aciclovir resistant ocular herpes simplex virus infections. Virology. 2017 Dec;512:194-200. doi: 10.1016/j.virol.2017.09.021. Epub 2017 Oct 3. PubMed PMID: 28985573.
