WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H562826
CAS#: 201788-90-1 (free base)
Description: 10-DEBC, also known as Akt Inhibitor X and CCG-206734, is a cell permeable phenoxazine derivative that suppresses insulin-like growth factor 1 (IGF-1)-stimulated phosphorylation of Akt. Inhibition of Akt phosphorylation by this compound strongly correlates to the inhibition of the downstream targets, mTOR, p70S6 kinase, and S6 ribosomal protein and to an increase in apoptosis.
Hodoodo Cat#: H562826
Name: 10-DEBC free base
CAS#: 201788-90-1 (free base)
Chemical Formula: C20H25ClN2O
Exact Mass: 344.17
Molecular Weight: 344.883
Elemental Analysis: C, 69.65; H, 7.31; Cl, 10.28; N, 8.12; O, 4.64
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 201788-90-1 (free base) 925681-41-0 (HCl)
Synonym: Akt Inhibitor X; Akt Inhibitor-X; aktX; 10-DEBC hydrochloride; CCG-206734; CCG 206734; CCG206734; NCP;
IUPAC/Chemical Name: 4-(2-chloro-10H-phenoxazin-10-yl)-N,N-diethylbutan-1-amine
InChi Key: GYBXAGDWMCJZJK-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H25ClN2O/c1-3-22(4-2)13-7-8-14-23-17-9-5-6-10-19(17)24-20-12-11-16(21)15-18(20)23/h5-6,9-12,15H,3-4,7-8,13-14H2,1-2H3
SMILES Code: CCN(CC)CCCCN1C2=C(C=CC=C2)OC3=CC=C(Cl)C=C13
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 344.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Varela-M RE, Ochoa R, Muskus CE, Muro A, Mollinedo F. Identification of a RAC/AKT-like gene in Leishmania parasites as a putative therapeutic target in leishmaniasis. Parasit Vectors. 2017 Oct 10;10(1):458. doi: 10.1186/s13071-017-2379-y. PubMed PMID: 29017516; PubMed Central PMCID: PMC5633885.
2: Zhang R, Zhu Y, Dong X, Liu B, Zhang N, Wang X, Liu L, Xu C, Huang S, Chen L. Celastrol Attenuates Cadmium-Induced Neuronal Apoptosis via Inhibiting Ca(2+) -CaMKII-Dependent Akt/mTOR Pathway. J Cell Physiol. 2017 Aug;232(8):2145-2157. doi: 10.1002/jcp.25703. Epub 2017 Feb 28. PubMed PMID: 27891586.
3: Xu C, Zhang H, Liu C, Zhu Y, Wang X, Gao W, Huang S, Chen L. Rapamycin inhibits Erk1/2-mediated neuronal apoptosis caused by cadmium. Oncotarget. 2015 Aug 28;6(25):21452-67. PubMed PMID: 26046303; PubMed Central PMCID: PMC4673278.
4: de Oliveira AC, Candelario-Jalil E, Langbein J, Wendeburg L, Bhatia HS, Schlachetzki JC, Biber K, Fiebich BL. Pharmacological inhibition of Akt and downstream pathways modulates the expression of COX-2 and mPGES-1 in activated microglia. J Neuroinflammation. 2012 Jan 3;9:2. doi: 10.1186/1742-2094-9-2. PubMed PMID: 22214188; PubMed Central PMCID: PMC3283507.
5: Lin Y, Sun Z. Thyroid hormone promotes insulin-induced glucose uptake by enhancing Akt phosphorylation and VAMP2 translocation in 3T3-L1 adipocytes. J Cell Physiol. 2011 Oct;226(10):2625-32. doi: 10.1002/jcp.22613. PubMed PMID: 21792921; PubMed Central PMCID: PMC3075354.
6: Banquet S, Delannoy E, Agouni A, Dessy C, Lacomme S, Hubert F, Richard V, Muller B, Leblais V. Role of G(i/o)-Src kinase-PI3K/Akt pathway and caveolin-1 in β₂-adrenoceptor coupling to endothelial NO synthase in mouse pulmonary artery. Cell Signal. 2011 Jul;23(7):1136-43. doi: 10.1016/j.cellsig.2011.02.008. Epub 2011 Mar 6. PubMed PMID: 21385608.
7: Shyu KG, Wang BW, Chen WJ, Kuan P, Hung CR. Mechanism of the inhibitory effect of atorvastatin on endoglin expression induced by transforming growth factor-beta1 in cultured cardiac fibroblasts. Eur J Heart Fail. 2010 Mar;12(3):219-26. doi: 10.1093/eurjhf/hfq011. PubMed PMID: 20156938.
8: Nagahama M, Hagiyama T, Kojima T, Aoyanagi K, Takahashi C, Oda M, Sakaguchi Y, Oguma K, Sakurai J. Binding and internalization of Clostridium botulinum C2 toxin. Infect Immun. 2009 Nov;77(11):5139-48. doi: 10.1128/IAI.00638-09. Epub 2009 Aug 31. PubMed PMID: 19720757; PubMed Central PMCID: PMC2772504.
9: Altamirano F, Oyarce C, Silva P, Toyos M, Wilson C, Lavandero S, Uhlén P, Estrada M. Testosterone induces cardiomyocyte hypertrophy through mammalian target of rapamycin complex 1 pathway. J Endocrinol. 2009 Aug;202(2):299-307. doi: 10.1677/JOE-09-0044. Epub 2009 May 27. Erratum in: J Endocrinol. 2009 Sep;202(3):485. PubMed PMID: 19474060.
10: Lim CS, Walikonis RS. Hepatocyte growth factor and c-Met promote dendritic maturation during hippocampal neuron differentiation via the Akt pathway. Cell Signal. 2008 May;20(5):825-35. doi: 10.1016/j.cellsig.2007.12.013. Epub 2007 Dec 27. PubMed PMID: 18262389; PubMed Central PMCID: PMC2302788.
