WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H558359
CAS#: 1092-46-2 (free base)
Description: Ketocaine is a local anesthetic used topically for pain relief.
Hodoodo Cat#: H558359
Name: Ketocaine
CAS#: 1092-46-2 (free base)
Chemical Formula: C18H29NO2
Exact Mass: 291.22
Molecular Weight: 291.430
Elemental Analysis: C, 74.18; H, 10.03; N, 4.81; O, 10.98
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 1092-46-2 (free base) 1092-47-3 (HCl)
Synonym: Ketocaine; Chetocaina; Ketocainum; Cetocaina;
IUPAC/Chemical Name: 2'-(2-(Diisopropylamino)ethoxy)butyrophenone
InChi Key: UXAWFWFJXIANHZ-UHFFFAOYSA-N
InChi Code: InChI=1S/C18H29NO2/c1-6-9-17(20)16-10-7-8-11-18(16)21-13-12-19(14(2)3)15(4)5/h7-8,10-11,14-15H,6,9,12-13H2,1-5H3
SMILES Code: CCCC(C1=CC=CC=C1OCCN(C(C)C)C(C)C)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 291.43 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Sandahl B, Ulmsten U, Andersson KE. Local application of ketocaine for treatment of referred pain in primary dysmenorrhea. Acta Obstet Gynecol Scand. 1980;59(3):259-60. PubMed PMID: 6999828.
2: Permin M, Ipsen L, Hansen MK, Andersen L, Petersen E, Rosengreen L, Søfensen MS, Bank D, Steffensen B, Gustafsson B. Relief from pain localized to the lower back in early labour. A double blind trial of ketocaine, a new, highly effective, local, cutaneous analgesic (A 2358, Ane-Pad), and placebo. Z Geburtshilfe Perinatol. 1981 Dec;185(6):360-3. PubMed PMID: 6461973.
3: Berlin-Wahlén A, Evers H, Haegerstam G, Vinnars E. Systemic absorption of ketocaine following epicutaneous administration. Acta Pharm Suec. 1981;18(3):113-8. PubMed PMID: 7324977.
4: Ulmsten U, Sandahl B, Lundén C, Andersson KE. Treatment of labor pain with locally applied ketocaine. Acta Obstet Gynecol Scand. 1980;59(3):209-12. PubMed PMID: 6999827.
5: Jouppila R, Nuoranne E, Tervilä L, Gustafsson B. Epicutaneous application of A2358 compresses containing ketocaine for pain relief in labor. A multicenter double-blind trial. Acta Obstet Gynecol Scand. 1983;62(4):321-4. PubMed PMID: 6227198.
6: Haegerstam G, Evers H, Juhlin L. Hyperaemia induced by topical application of anaesthetic formulations containing ketocaine. Scand J Plast Reconstr Surg. 1979;13(3):469-71. PubMed PMID: 542818.
7: Smythe GE. Skin penetration of ketocaine. Br J Anaesth. 1979 Dec;51(12):1189-90. PubMed PMID: 526389.
8: Berlin-Wahlén A, Sandberg R. Biotransformation and elimination of ketocaine in rats. Acta Pharm Suec. 1977;14(4):321-34. PubMed PMID: 930592.
9: Jouppila R, Teramo K, Ulmsten U, Purhonen M, Hollmén A, Berlin-Wahlén A, Gustafsson B. Maternal and foetal drug levels after epicutaneous application of a local anaesthetic formulation containing ketocaine for possible use as pain relief in labour. Acta Anaesthesiol Scand. 1981 Feb;25(1):73-5. PubMed PMID: 7293707.
10: Ardizzone F, Ariano M, Galatulas I. [Ketocaine as an activator of oxygen consumption by cerebral tissue]. Boll Soc Ital Biol Sper. 1968 Jan 15;44(1):60-4. Italian. PubMed PMID: 5664660.
11: Pontén B, Ohlsén L. Skin surface application of ketocaine to provide local anaesthesia for cutting split skin grafts. Br J Plast Surg. 1977 Oct;30(4):251-4. PubMed PMID: 338067.
12: Berlin-Wahlén A, Högberg K, Lindgren JE, Vecchietti M. Determination of ketocaine blood concentrations following brachial plexus block and epicutaneous administration. Acta Pharm Suec. 1977;14(5-6):425-34. PubMed PMID: 596161.
13: Bongrani S, Colla B, Ferrari O. Inotropic effects on the isolated heart of the guinea pig of an antiarrhythmic drug derived from ketocaine. Farmaco Prat. 1975 Jul;30(7):347-55. PubMed PMID: 1157915.
14: Hallin RG. Blocking effects of a topical anesthetic composition containing Ketocaine on cutaneous C receptor responses in alert man. Acta Anaesthesiol Scand. 1974;18(4):306-17. PubMed PMID: 4375396.
15: Carruba M, Galatulas I, Pomarelli P. [Effects of a series of ketocaine homologues on neuromuscular transmission]. Atti Accad Med Lomb. 1970;25(2-3):162-8. Italian. PubMed PMID: 4377222.
16: Bossa R, Dubini F, Galatulas I, Taniguchi M. [Antimitotic activity of formicin, ketocaine and chloroimipramine on human leukocytes in culture stimulated with phytohemagglutinin]. Arch Ital Patol Clin Tumori. 1970 Jul-Dec;13(3):135-40. Italian. PubMed PMID: 5521382.
17: Pollazzon G, Papi B. [Comparative evaluation of a new local anesthetic (Rec. 7-0518 or ketocaine) in continuous peridural anesthesia]. Acta Anaesthesiol. 1968;19:Suppl 9:187+. Italian. PubMed PMID: 5757611.
18: Pettersson LO, Strömbeck JO. Percutaneous anaesthesia for dermabrasion. Scand J Plast Reconstr Surg. 1978;12(3):287-90. PubMed PMID: 741219.
19: Andreani A, Bonazzi D, Rambaldi M, Galatulas I, Bossa R. Potential antitumor agents X: Synthesis and antitumor activity of two nitrogen mustard derivatives related to ketocaine. J Pharm Sci. 1984 Aug;73(8):1175-7. PubMed PMID: 6548522.
20: Andreani A, Scapini G, Galatulas I, Bossa R. Potential antitumor agents IX: synthesis and antitumor activity of two analogues of ketocaine. J Pharm Sci. 1983 Jul;72(7):814-5. PubMed PMID: 6886989.
