Prednisolone valerate acetate

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H598841

CAS#: 72064-79-0 (valerate acetate)

Description: Prednisolone valerate acetate is a derivative of Prednisolone, which is a synthetic corticosteroid, metabolically interconvertible with prednisone, and an impurity of Hydrocortisone. Prednisolone 21-Acetate Valerate is used in multifunctional nanoemulsion platform for imaging guided therapy evaluated in experimental cancer.

Chemical Structure

img
Prednisolone valerate acetate
CAS# 72064-79-0 (valerate acetate)
Instruction

Theoretical Analysis

Hodoodo Cat#: H598841
Name: Prednisolone valerate acetate
CAS#: 72064-79-0 (valerate acetate)
Chemical Formula: C28H38O7
Exact Mass: 486.26
Molecular Weight: 486.605
Elemental Analysis: C, 69.11; H, 7.87; O, 23.02

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Related CAS #: 52-21-1 (acetate)   72064-79-0 (valerate acetate)   630-67-1 (sodium metazoate)   125-02-0 (Na+ phosphate)   50-24-8 (free)  

Synonym: Prednisolone valerate acetate; Lidomex; Acepreval;

IUPAC/Chemical Name: (8S,9S,10R,11S,13S,14S,17R)-17-(2-acetoxyacetyl)-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl pentanoate

InChi Key: DGYSDXLCLKPUBR-SLPNHVECSA-N

InChi Code: InChI=1S/C28H38O7/c1-5-6-7-24(33)35-28(23(32)16-34-17(2)29)13-11-21-20-9-8-18-14-19(30)10-12-26(18,3)25(20)22(31)15-27(21,28)4/h10,12,14,20-22,25,31H,5-9,11,13,15-16H2,1-4H3/t20-,21-,22-,25+,26-,27-,28-/m0/s1

SMILES Code: C[C@@]12[C@](C(COC(C)=O)=O)(OC(CCCC)=O)CC[C@@]1([H])[C@]3([H])CCC4=CC(C=C[C@]4(C)[C@@]3([H])[C@@H](O)C2)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
Soluble in DMSO 0.0 100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 486.61 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Vitali C. [Percutaneous absorption of prednisolone 17-valerate-21-acetate, a new corticosteroid for topical use]. Clin Ter. 1978 Apr 30;85(2):173-7. Italian. PubMed PMID: 657747.

2: Kobayashi F, Hattori Y, Koshi T, Nagoya T. [Effect of prednisolone 17-valerate 21-acetate on immunological responses in mice (author's transl)]. Nihon Yakurigaku Zasshi. 1980 Sep;76(5):363-72. Japanese. PubMed PMID: 7203277.

3: Wada Y, Etoh Y, Ohira A, Ikuta J, Kato Y, Sano N. [Anti-inflammatory effects of prednisolone 17-valerate 21-acetate, a new topical corticosteroid (author's transl)]. Nihon Yakurigaku Zasshi. 1980 Sep;76(5):333-45. Japanese. PubMed PMID: 7203275.

4: Garretts M. Controlled double-blind comparative trial with fluprednylidene acetate cream and its base. Arch Dermatol Forsch. 1975;251(3):165-8. PubMed PMID: 1091216.

5: Miyamoto A, Kitaichi Y, Uchikura K. Degradation of corticosteroids during activated sludge processing. Chem Pharm Bull (Tokyo). 2014;62(1):72-6. PubMed PMID: 24390495.

6: Nakano M, Takeuchi M, Sugeno K. Effects of dexamethasone 17-esters on adrenal weight and hydrolysis of glucocorticoid 17-esters in rat fetuses. J Pharmacobiodyn. 1981 Mar;4(3):211-6. PubMed PMID: 7252770.

7: Bircher AJ, Levy F, Langauer S, Lepoittevin JP. Contact allergy to topical corticosteroids and systemic contact dermatitis from prednisolone with tolerance of triamcinolone. Acta Derm Venereol. 1995 Nov;75(6):490-3. Review. PubMed PMID: 8651033.

8: Gianella A, Jarzyna PA, Mani V, Ramachandran S, Calcagno C, Tang J, Kann B, Dijk WJ, Thijssen VL, Griffioen AW, Storm G, Fayad ZA, Mulder WJ. Multifunctional nanoemulsion platform for imaging guided therapy evaluated in experimental cancer. ACS Nano. 2011 Jun 28;5(6):4422-33. doi: 10.1021/nn103336a. Epub 2011 May 25. PubMed PMID: 21557611; PubMed Central PMCID: PMC3296132.

9: Rampini E, Rastelli A, Cardo P. Comparative study of the vasoconstrictor activity of halopredone acetate in a modified McKenzie test. Eur J Clin Pharmacol. 1978 Dec 18;14(5):325-9. PubMed PMID: 729625.

10: Nomiyama T, Takenaka H, Kishimoto S, Katoh N. Granuloma annulare-like reaction to the bacillus Calmette-Guerin vaccination. Australas J Dermatol. 2013 Feb;54(1):e4-7. doi: 10.1111/j.1440-0960.2011.00814.x. Epub 2011 Sep 20. PubMed PMID: 23373894.

11: Kimura M, Tarumoto Y, Nakane S, Otomo S. Comparative toxicity study of hydrocortisone 17-butyrate 21-propionate (HBP) ointment and other topical corticosteroids in rats. Drugs Exp Clin Res. 1986;12(8):643-52. PubMed PMID: 3757761.

12: Singh PK, Singh G. Relative Potency of Topical Corticosteroid Preparations. Indian J Dermatol Venereol Leprol. 1985 Nov-Dec;51(6):309-312. PubMed PMID: 28164900.

13: Mizushima Y, Igarashi R, Hoshi K, Muramatsu M, Fujita A. Increase in incorporation into lymphocytes in vitro of esterified anti-inflammatory corticosteroids. Agents Actions. 1986 Oct;19(1-2):123-6. PubMed PMID: 3799370.

14: Lubach D, Kietzmann M. Investigation of the skin thinning effect of prednicarbate and other corticoids in mouse skin. Skin Pharmacol. 1988;1(3):200-6. PubMed PMID: 3272751.

15: Luzzani F, Gallico L, Glässer A. In vitro and ex vivo binding to uterine progestin receptors of the rat as a tool to assay progestational activity of glucocorticoids. Methods Find Exp Clin Pharmacol. 1982;4(4):237-42. PubMed PMID: 7121132.

16: Blaschke T, Kankate L, Kramer KD. Structure and dynamics of drug-carrier systems as studied by parelectric spectroscopy. Adv Drug Deliv Rev. 2007 Jul 10;59(6):403-10. Epub 2007 May 3. PubMed PMID: 17573146.

17: Ko DH, Heiman AS, Hudson CE, Lee HJ. New steroidal antiinflammatory antedrugs: Methyl 3,20-dioxo-9 alpha-fluoro-11 beta,17 alpha,21-trihydroxy-1,4-pregnadiene-16 alpha-carboxylate and its 21-O-acyl derivatives. Steroids. 2002 Mar;67(3-4):211-9. PubMed PMID: 11856545.

18: Bayes M, Rabasseda X, Prous JR. Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2002 May;24(4):217-48. Review. PubMed PMID: 12092009.