WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H599014
CAS#: 488127-53-3 (lithium)
Description: Topiramate lithium is a broad-spectrum anticonvulsant (antiepilepsy) drug. In late 2012, topiramate was approved by the United States Food and Drug Administration (FDA) in combination with phentermine for weight loss.
Hodoodo Cat#: H599014
Name: Topiramate lithium
CAS#: 488127-53-3 (lithium)
Chemical Formula: C12H20LiNO8S
Exact Mass: 0.00
Molecular Weight: 345.290
Elemental Analysis: C, 41.74; H, 5.84; Li, 2.01; N, 4.06; O, 37.07; S, 9.28
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 488127-53-3 (lithium) 97240-79-4 (free base)
Synonym: Topiramate lithium; Lithium topiramate;
IUPAC/Chemical Name: lithium ((((3aS,5aR,8aR,8bS)-2,2,7,7-tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-3a-yl)methoxy)sulfonyl)amide
InChi Key: FRVIGWXXRZKZOL-WGAVTJJLSA-N
InChi Code: InChI=1S/C12H20NO8S.Li/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12;/h7-9H,5-6H2,1-4H3,(H-,13,14,15);/q-1;+1/t7-,8-,9+,12+;/m1./s1
SMILES Code: CC1(O[C@H]([C@@H](CO[C@@]2(COS(=O)([NH-])=O)O3)O1)[C@@H]2OC3(C)C)C.[Li+]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 345.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
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18: Maksimovic M, Vekovischeva OY, Aitta-aho T, Korpi ER. Chronic treatment with mood-stabilizers attenuates abnormal hyperlocomotion of GluA1-subunit deficient mice. PLoS One. 2014 Jun 16;9(6):e100188. doi: 10.1371/journal.pone.0100188. eCollection 2014. PubMed PMID: 24932798; PubMed Central PMCID: PMC4059755.
19: Chengappa KN, Gershon S, Levine J. The evolving role of topiramate among other mood stabilizers in the management of bipolar disorder. Bipolar Disord. 2001 Oct;3(5):215-32. Review. PubMed PMID: 11912568.
20: François J, Koning E, Ferrandon A, Nehlig A. The combination of topiramate and diazepam is partially neuroprotective in the hippocampus but not antiepileptogenic in the lithium-pilocarpine model of temporal lobe epilepsy. Epilepsy Res. 2006 Dec;72(2-3):147-63. Epub 2006 Sep 1. PubMed PMID: 16945504.