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Halofuginone Hydrobromide
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WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H563947

CAS#: 64924-67-0 (HBr)

Description: Halofuginone Hydrobromide is a potent prolyl-tRNA synthetase inhibitor.

Chemical Structure

Halofuginone Hydrobromide

CAS# 64924-67-0 (HBr)

Instruction

Theoretical Analysis

Hodoodo Cat#: H563947
Name: Halofuginone Hydrobromide
CAS#: 64924-67-0 (HBr)
Chemical Formula: C16H18Br2ClN3O3
Exact Mass: 492.94
Molecular Weight: 495.600
Elemental Analysis: C, 38.78; H, 3.66; Br, 32.25; Cl, 7.15; N, 8.48; O, 9.68

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 550	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. Hodoodo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Related CAS #: 55837-20-2 (free base) 64924-67-0 (HBr) 1217623-74-9 (HCl) 82186-71-8 (lactate)

Synonym: Halofuginone HBr; Halofuginone-HBr; HalofuginoneHBr; Halofuginone hydrobromide; Halofuginone-hydrobromide; Halofuginonehydrobromide

IUPAC/Chemical Name: (2R*,3S*)-7-Bromo-6-chloro-3-[3-(3-hydroxy-2-piperidinyl)-2-oxopropyl]-4-3H-quinazolinone hydrobromide

InChi Key: SJUWEPZBTXEUMU-LIOBNPLQSA-N

InChi Code: InChI=1S/C16H17BrClN3O3.BrH/c17-11-6-13-10(5-12(11)18)16(24)21(8-20-13)7-9(22)4-14-15(23)2-1-3-19-14;/h5-6,8,14-15,19,23H,1-4,7H2;1H/t14-,15+;/m1./s1

SMILES Code: O=C1N(CC(C[C@H]2NCCC[C@@H]2O)=O)C=NC3=C1C=C(Cl)C(Br)=C3.[H]Br

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >3 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.03.00

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 495.60 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

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1: Zhang J, Yao Q, Liu Z. A Novel Synthesis of the Efficient Anti-Coccidial Drug Halofuginone Hydrobromide. Molecules. 2017 Jun 30;22(7). pii: E1086. doi: 10.3390/molecules22071086. PubMed PMID: 28665346.

2: Zhang DF, Sun BB, Yue YY, Yu HJ, Zhang HL, Zhou QJ, Du AF. Anticoccidial effect of halofuginone hydrobromide against Eimeria tenella with associated histology. Parasitol Res. 2012 Aug;111(2):695-701. doi: 10.1007/s00436-012-2889-7. Epub 2012 Mar 14. PubMed PMID: 22415441.

3: Lista S, Emanuele E. Potential therapeutical effects of topical halofuginone hydrobromide in keloid management. Med Hypotheses. 2007;69(3):707. Epub 2007 Feb 28. PubMed PMID: 17331662.

4: Holland DC, Munns RK, Roybal JE, Hurlbut JA, Long AR. Liquid chromatographic determination of the anticoccidial drug halofuginone hydrobromide in eggs. J AOAC Int. 1995 Jan-Feb;78(1):37-40. PubMed PMID: 7703725.

5: Determination of halofuginone hydrobromide in medicated animal feeds. Analyst. 1983 Oct;108(1291):1252-6. PubMed PMID: 6650842.

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Halofuginone Hydrobromide featured