WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H555355
CAS#: 145645-62-1 (HCl)
Description: NO-711, also known as NNC-711, is a potent and selective GABA uptake inhibitor that crosses the blood-brain barrier. NO-711 alters the EEG power spectra and enhances non-rapid eye movement sleep during the active phase in mice.NO-711 potentiates 3-aminopropylphosphinic acid-induced actions in rat neocortical slices.
Hodoodo Cat#: H555355
Name: NO-711 HCl
CAS#: 145645-62-1 (HCl)
Chemical Formula: C21H23ClN2O3
Exact Mass: 0.00
Molecular Weight: 386.876
Elemental Analysis: C, 65.20; H, 5.99; Cl, 9.16; N, 7.24; O, 12.41
Related CAS #: 159094-94-7 (free base) 145645-62-1 (HCl)
Synonym: NO-711 HCl; NO-711 hydrochloride; NO-711; NO 711; NO711; NNC-711 hydrochloride; NNC-711; NNC 711; NNC711 HCl;
IUPAC/Chemical Name: 1,2,5,6-Tetrahydro-1-[2-[[(diphenylmethylene)amino]oxy]ethyl]-3-pyridinecarboxylic acid hydrochloride
InChi Key: YZYRTEYMUTWJPL-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H22N2O3.ClH/c24-21(25)19-12-7-13-23(16-19)14-15-26-22-20(17-8-3-1-4-9-17)18-10-5-2-6-11-18;/h1-6,8-12H,7,13-16H2,(H,24,25);1H
SMILES Code: O=C(C1=CCCN(CCO/N=C(C2=CC=CC=C2)\C3=CC=CC=C3)C1)O.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.03.00
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 386.88 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Xu XH, Qiu MH, Dong H, Qu WM, Urade Y, Huang ZL. GABA transporter-1 inhibitor NO-711 alters the EEG power spectra and enhances non-rapid eye movement sleep during the active phase in mice. Eur Neuropsychopharmacol. 2014 Apr;24(4):585-94. doi: 10.1016/j.euroneuro.2013.09.002. Epub 2013 Sep 12. PubMed PMID: 24080505.
2: Li Y, Li Y, Gu P, Fu B, Liu F, Li E. Analgesic effect of intrathecally γ-aminobutyric acid transporter-1 inhibitor NO-711 administrating on neuropathic pain in rats. Neurosci Lett. 2011 Apr 20;494(1):6-9. doi: 10.1016/j.neulet.2011.02.028. Epub 2011 Feb 23. PubMed PMID: 21352893.
3: Zhu SS, Zeng YM, Wang JK, Yan R, Nie X, Cao JL. Inhibition of thermal hyperalgesia and tactile allodynia by intrathecal administration of gamma-aminobutyric acid transporter-1 inhibitor NO-711 in rats with chronic constriction injury. Sheng Li Xue Bao. 2005 Apr 25;57(2):233-9. PubMed PMID: 15830110.
4: Hanitzsch R, Küppers L, Flade A. The effect of GABA and the GABA-uptake-blocker NO-711 on the b-wave of the ERG and the responses of horizontal cells to light. Graefes Arch Clin Exp Ophthalmol. 2004 Sep;242(9):784-91. PubMed PMID: 15069568.
5: Stokes AH, Bernard LP, Nicklas WJ, Zeevalk GD. Attenuation of malonate toxicity in primary mesencephalic cultures using the GABA transport blocker, NO-711. J Neurosci Res. 2001 Apr 1;64(1):43-52. PubMed PMID: 11276050.
6: Ong J, Kerr DI. The gamma-aminobutyric acid uptake inhibitor NO-711 potentiates 3-aminopropylphosphinic acid-induced actions in rat neocortical slices. Eur J Pharmacol. 1998 Apr 24;347(2-3):197-200. PubMed PMID: 9653881.
