WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H207064
CAS#: 2071684-09-6 (HCl)
Description: NLG802 is an orally bioavailable prodrug of indoximod, a methylated tryptophan, with immune checkpoint inhibitory and antineoplastic activities. Upon oral administration, the indoximod prodrug NLG802 is converted to indoximod. Indoximod targets, binds to and inhibits the enzyme indoleamine 2,3-dioxygenase (IDO; IDO1), which converts the essential amino acid tryptophan into the immunosuppressive metabolite kynurenine. By increasing tryptophan levels and decreasing kynurenine levels, indoximod restores and promotes the proliferation and activation of various immune cells, including dendritic cells (DCs), natural killer (NK) cells, and T lymphocytes, and causes a reduction in tumor-associated regulatory T cells (Tregs).
Hodoodo Cat#: H207064
Name: NLG802 HCl
CAS#: 2071684-09-6 (HCl)
Chemical Formula: C18H26ClN3O3
Exact Mass: 0.00
Molecular Weight: 367.874
Elemental Analysis: C, 58.77; H, 7.12; Cl, 9.64; N, 11.42; O, 13.05
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Related CAS #: 2071684-08-5 (free base) 2071684-09-6 (HCl)
Synonym: NLG802; NLG-802; NLG 802; NLG802 HCl;
IUPAC/Chemical Name: Na-(L-leucyl)-1-methyl-D-tryptophan hydrochloride
InChi Key: AUVNEVXWZKBPCE-LDXVYITESA-N
InChi Code: InChI=1S/C18H25N3O3.ClH/c1-11(2)8-14(19)17(22)20-15(18(23)24)9-12-10-21(3)16-7-5-4-6-13(12)16;/h4-7,10-11,14-15H,8-9,19H2,1-3H3,(H,20,22)(H,23,24);1H/t14-,15+;/m0./s1
SMILES Code: O=C(O)[C@@H](CC1=CN(C)C2=C1C=CC=C2)NC([C@H](CC(C)C)N)=O.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: Activation of the immune system, which is suppressed in many cancers, may induce a cytotoxic T-lymphocyte (CTL) response against IDO1-expressing tumor cells, thereby inhibiting their growth. IDO1, overexpressed by multiple tumor cell types, plays an important role in immunosuppression. Tryptophan depletion inhibits T-lymphocyte proliferation and activation, and subsequently suppresses the immune system. NLG802 elicits increased plasma concentrations of indoximod and improves its efficacy, compared to the direct administration of indoximod.
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The following data is based on the product molecular weight 367.87 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
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