WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H584839
CAS#: 99453-84-6 (free base)
Description: Neltenexine is an elastase inhibitor that may be useful for preventing pulmonary emphysema.
Hodoodo Cat#: H584839
Name: Neltenexine
CAS#: 99453-84-6 (free base)
Chemical Formula: C18H20Br2N2O2S
Exact Mass: 485.96
Molecular Weight: 488.238
Elemental Analysis: C, 44.28; H, 4.13; Br, 32.73; N, 5.74; O, 6.55; S, 6.57
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 99453-84-6 (free base) 99461-80-0 (HCl)
Synonym: Neltenexine
IUPAC/Chemical Name: N-(2,4-Dibromo-6-{[(trans-4-hydroxycyclohexyl)amino]methyl}phenyl)-2-thiophenecarboxamide
InChi Key: SSLHKNBKUBAHJY-HDJSIYSDSA-N
InChi Code: InChI=1S/C18H20Br2N2O2S/c19-12-8-11(10-21-13-3-5-14(23)6-4-13)17(15(20)9-12)22-18(24)16-2-1-7-25-16/h1-2,7-9,13-14,21,23H,3-6,10H2,(H,22,24)/t13-,14-
SMILES Code: O=C(C1=CC=CS1)NC2=C(CN[C@H]3CC[C@H](O)CC3)C=C(Br)C=C2Br
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 488.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Niisato N, Hasegawa I, Tokuda S, Taruno A, Nakajima K, Miyazaki H, Iwasaki Y, Marunaka Y. Action of neltenexine on anion secretion in human airway epithelia. Biochem Biophys Res Commun. 2007 May 18;356(4):1050-5. Epub 2007 Mar 26. PubMed PMID: 17400191.
2: Cattaneo C. Neltenexine tablets in smoking and non-smoking patients with COPD. A double-blind, randomised, controlled study versus placebo. Minerva Med. 2001 Aug;92(4):277-84. PubMed PMID: 11535971.
3: Fadda G. Oral neltenexine in patients with obstructive airways diseases: an open, randomised, controlled comparison versus sobrerol. Minerva Med. 2001 Aug;92(4):269-75. PubMed PMID: 11535970.
4: Braga PC, Piatti G, Limoli A, Dal Sasso M, Maci S. Neltenexine: morphological investigation of protection against elastase-induced emphysema in rats. Drugs Exp Clin Res. 1995;21(2):51-7. PubMed PMID: 7555609.
5: Chang CC, Cheng AC, Chang AB. Over-the-counter (OTC) medications to reduce cough as an adjunct to antibiotics for acute pneumonia in children and adults. Cochrane Database Syst Rev. 2014 Mar 10;(3):CD006088. doi: 10.1002/14651858.CD006088.pub4. Review. PubMed PMID: 24615334.
6: Molassiotis A, Bryan G, Caress A, Bailey C, Smith J. Pharmacological and non-pharmacological interventions for cough in adults with respiratory and non-respiratory diseases: A systematic review of the literature. Respir Med. 2010 Jul;104(7):934-44. doi: 10.1016/j.rmed.2010.02.010. Epub 2010 Apr 10. Review. PubMed PMID: 20385478.
7: Chang CC, Cheng AC, Chang AB. Over-the-counter (OTC) medications to reduce cough as an adjunct to antibiotics for acute pneumonia in children and adults. Cochrane Database Syst Rev. 2012 Feb 15;(2):CD006088. doi: 10.1002/14651858.CD006088.pub3. Review. Update in: Cochrane Database Syst Rev. 2014;(3):CD006088. PubMed PMID: 22336815.
8: Chang CC, Cheng AC, Chang AB. Over-the-counter (OTC) medications to reduce cough as an adjunct to antibiotics for acute pneumonia in children and adults. Cochrane Database Syst Rev. 2007 Oct 17;(4):CD006088. Review. Update in: Cochrane Database Syst Rev. 2012;2:CD006088. PubMed PMID: 17943884.
