WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H555784
CAS#: 1172854-54-4 (HCl)
Description: NS-3-008 is an orally active transcriptional inhibitor of G0/G1 switch 2 (G0s2). NS-3-008 can be used for chronic kidney disease. NS-3-008 inhibited the transcription of G0s2 with a half-maximal inhibitory concentration (IC50) of 2.25 μM. Moreover, treatment of wild-type 5/6Nx mice with NS-3-008 (5 mg/kg, P.O.) resulted in decreased levels of G0s2 and Ccl2 mRNA in the kidneys.
Hodoodo Cat#: H555784
Name: NS-3-008 HCl
CAS#: 1172854-54-4 (HCl)
Chemical Formula: C14H24ClN3
Exact Mass: 0.00
Molecular Weight: 269.817
Elemental Analysis: C, 62.32; H, 8.97; Cl, 13.14; N, 15.57
Related CAS #: 1172854-54-4 (free base) 1172854-54-4 (HCl)
Synonym: NS-3-008 HCl; NS-3-008 hydrochloride; NS-3-008; NS 3-008; NS3-008; NS-3008; NS 3008; NS3008;
IUPAC/Chemical Name: 1-benzyl-3-hexylguanidine hydrochloride
InChi Key: UMIOAATZOCKZTH-UHFFFAOYSA-N
InChi Code: InChI=1S/C14H23N3.ClH/c1-2-3-4-8-11-16-14(15)17-12-13-9-6-5-7-10-13;/h5-7,9-10H,2-4,8,11-12H2,1H3,(H3,15,16,17);1H
SMILES Code: N=C(NCC1=CC=CC=C1)NCCCCCC.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: Chronic kidney disease (CKD) is a global health problem, and novel therapies to treat CKD are urgently needed. Chronic renal inflammation in CKD was ameliorated by clock mutation. G0s2 was important for the anti-inflammatory effects of clock mutation.
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The following data is based on the product molecular weight 269.82 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
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https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(16)30463-7/fulltext
