WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H462268
CAS#: 1952264-33-3
Description: ZEN-3862 is a BET inhibitor and can be used to form PROTACs to induce degradation of BRD4.
Hodoodo Cat#: H462268
Name: ZEN-3862
CAS#: 1952264-33-3
Chemical Formula: C19H17FN2O3
Exact Mass: 340.12
Molecular Weight: 340.354
Elemental Analysis: C, 67.05; H, 5.03; F, 5.58; N, 8.23; O, 14.10
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Synonym: ZEN-3862; ZEN3862; ZEN 3862
IUPAC/Chemical Name: 5-(3,5-dimethylisoxazol-4-yl)-1-(3-fluoro-4-(oxiran-2-yl)benzyl)pyridin-2(1H)-one
InChi Key: VQHDSZCBMWYGEK-UHFFFAOYSA-N
InChi Code: InChI=1S/C19H17FN2O3/c1-11-19(12(2)25-21-11)14-4-6-18(23)22(9-14)8-13-3-5-15(16(20)7-13)17-10-24-17/h3-7,9,17H,8,10H2,1-2H3
SMILES Code: FC1=C(C2OC2)C=CC(CN3C(C=CC(C4=C(C)ON=C4C)=C3)=O)=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 340.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Kharenko OA, Patel RG, Brown SD, et al. Design and Characterization of Novel Covalent Bromodomain and Extra-Terminal Domain (BET) Inhibitors Targeting a Methionine. J Med Chem. 2018;61(18):8202-8211. doi:10.1021/acs.jmedchem.8b00666