Welcome to Hodoodo Chemicals

Glisoxepide
featured

WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H317974

CAS#: 25046-79-1

Description: Glisoxepide is a second-generation sulfonylurea with antihyperglycemic activity. Like other second-generation compounds, glisoxepide exerts greater binding affinity than the first-generation compounds. Glisoxepide shows peroxisome proliferator-activated receptor gamma agonistic activity, has a short half-life and is excreted in both the bile and urine.

Chemical Structure

Glisoxepide

CAS# 25046-79-1

Instruction

Theoretical Analysis

Hodoodo Cat#: H317974
Name: Glisoxepide
CAS#: 25046-79-1
Chemical Formula: C20H27N5O5S
Exact Mass: 449.17
Molecular Weight: 449.239
Elemental Analysis: C, 53.44; H, 6.05; N, 15.58; O, 17.80; S, 7.13

Price and Availability

Size	Price	Availability	Quantity
10mg	USD 510
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. Hodoodo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Glisoxepide; Glisoxepid; Pro-Diaban; Glisepin; Glisoxepida [Spanish]; Glisoxepida; BS 4231; BS-4231; glisoxepid; glisoxepide; Pro-diaban; RP 22410; RP-22410;

IUPAC/Chemical Name: N-[2-[4-(azepan-1-ylcarbamoylsulfamoyl)phenyl]ethyl]-5-methyl-1,2-oxazole-3-carboxamide

InChi Key: ZKUDBRCEOBOWLF-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H27N5O5S/c1-15-14-18(23-30-15)19(26)21-11-10-16-6-8-17(9-7-16)31(28,29)24-20(27)22-25-12-4-2-3-5-13-25/h6-9,14H,2-5,10-13H2,1H3,(H,21,26)(H2,22,24,27)

SMILES Code: CC1=CC(=NO1)C(=O)NCCC2=CC=C(C=C2)S(=O)(=O)NC(=O)NN3CCCCCC3

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO, not in water

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 449.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt* g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1

Volume 1

Concentration 2

Volume 2

1: Gutsche H, Losert W. [Clinico-pharmacological studies on the duration of
action of the oral antidiabetic drug glisoxepide (author's transl)].
Arzneimittelforschung. 1977;27(9):1719-26. German. PubMed PMID: 336058.

2: Blumenbach L, Kiesselbach N, Lehnert J. [Further results of a multi-centre
clinical trial with the oral antidiabetic drug glisoxepide (author's transl)].
Arzneimittelforschung. 1976;26(5):931-43. German. PubMed PMID: 786303.

3: Lehnert J, Kiesselbach NH, Blumenbach L. [Multicentric clinical proof of a new
oral antidiabetic glisoxepide (BS 4231). 1. Establishment of proof and methods].
Arzneimittelforschung. 1974 Mar;24(0):433-7. German. PubMed PMID: 4603693.

4: Puls W, Losert W, Loge O, Schillinger E, Keup U, Kroneberg G. [The
pharmacology of glisoxepide, a new oral antidiabetic]. Arzneimittelforschung.
1974 Mar;24(0):375-92. German. PubMed PMID: 4408136.

5: Schlossmann K. [Protein binding of glisoxepide and its influence on the
protein binding of phenprocoumon]. Arzneimittelforschung. 1974 Mar;24(0):392-7.
German. PubMed PMID: 4408096.

6: Birk W, Petrides P. [Behavior of serum insulin under the influence of
glisoxepide with and without butylbiguanide]. Arzneimittelforschung. 1974
Mar;24(0):425-9. German. PubMed PMID: 4408033.

7: Haupt E, Beyer J, Schöffling K. [Pharmacologic study with glisoxepide and
other blood sugar reducing sulfonamide derivatives in metabolically healthy
subjects and diabetics]. Arzneimittelforschung. 1974 Mar;24(0):418-25. German.
PubMed PMID: 4211557.

8: Loubatiéres A, Mariani MM, Ribes G, Alric R. Pharmacological comparison
between tolbutamide and two second generation hypoglycemic sulfonylureas
(glibenclamide and glisoxepide). Acta Diabetol Lat. 1973 Mar-Apr;10(2):261-82.
PubMed PMID: 4200675.

9: Loubatières AL, Ribes G, Loubatières-Mariani MM. [Effect of glycemia level on
insulin secretion caused by an hypoglycemic sulfamide (glisoxepide) in dogs]. C R
Seances Soc Biol Fil. 1972;166(8):1047-50. French. PubMed PMID: 4573746.

10: Haupt E, Köberich W, Beyer J, Schöffling K. Pharmacodynamic aspects of
tolbutamide, glibenclamide, glibornuride, and glisoxepide. II. Repeated
administration in combination with glucose. Diabetologia. 1971 Dec;7(6):455-60.
PubMed PMID: 5004179.

11: Irsigler K, Ogris E, Steinhardt T, Brändle J, Regal H, Zdolsek I. [Comparison
of glibenclamide, gliquidone, glisoxepide and placebo in maturity onset diabetics
of differing degrees of severity (author's transl)]. Wien Klin Wochenschr. 1979
Aug 31;91(16):541-50. German. PubMed PMID: 115159.

12: Hausmann L, Schumann G, Kaffarnik H. [Insulin and pro-insulin secretion
following intravenous administration of tolbutamide, glisoxepide and
glibenclamide]. Arzneimittelforschung. 1978;28(1):83-6. German. PubMed PMID:
415745.

13: Happ J, Beyer J, Ulreich F, Schöffling K, Krause U, Frönlich A. [Glisoxepide
treatment in maturity-onset diabetics (author's transl)]. Dtsch Med Wochenschr.
1976 Nov 5;101(45):1643-6. German. PubMed PMID: 1033056.

14: Nieuweboer B, Gabriel D, Lübke K. A method for radioimmunological assay of
glisoxepide (author's transl). Arzneimittelforschung. 1976;26(9):1633-6. German.
PubMed PMID: 1036690.

15: Söling HD, Seck A. Precursor specific inhibition of hepatic gluconeogenesis
by glisoxepide, an inhibitor of the L-aspartate/L-glutamate antiport system. FEBS
Lett. 1975 Mar 1;51(1):52-9. PubMed PMID: 235462.

16: Kiesselbach NH, Blumenbach L, Lehnert J. [Multicentric clinical proof of a
new oral antidiabetic glisoxepide (BS 4231). 3. Results of tolerance tests].
Arzneimittelforschung. 1974 Mar;24(0):447-52. German. PubMed PMID: 4603694.

17: Blumenbach L, Kiesselbach NH, Lehnert J. [Multicentric clinical proof of a
new oral antidiabetic glisoxepide (BS 4231). II. Proof of activity in the
management of adult onset diabetes]. Arzneimittelforschung. 1974
Mar;24(0):437-46. German. PubMed PMID: 4603692.

18: Petzoldt R, Riedesel G, Ramrath M, Grabs V, Haupt E, Schwedes U, Ewald W,
Beyer J, Schöffling K. [Clinical experience with the blood sugar reducing
sulfonamide derivative glisoxepide]. Arzneimittelforschung. 1974
Mar;24(0):429-32. German. PubMed PMID: 4603399.

19: Tettenborn D. [The toxicology of glisoxepide, a new oral antidiabetic.
Results of animal studies]. Arzneimittelforschung. 1974 Mar;24(0):409-18. German.
PubMed PMID: 4408138.

20: Speck U, Mützel W, Kolb KH, Acksteiner B, Schulze PE. [Pharmacokinetics and
metabolite spectrum of glisoxepide in humans]. Arzneimittelforschung. 1974
Mar;24(0):404-9. German. PubMed PMID: 4408089.