WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H462765
CAS#: 870087-37-9 (HCl)
Description: Apilimod dimesylate is a potent and selective PIKfyve inhibitor. It exhibits no significant activity at other lipid kinases and protein kinases, including PIP4K, PIP5K, mTOR, PI3K and PI4K. Apilimod dimesylate inhibits cellular entry by SARS-CoV-2, MERS-CoV and MHV S pseudovirions. It reduces the number of SARS-CoV-2-infected hiPSC-derived pneumocyte-like cells by 85% and inhibits SARS-CoV-2 replication in donor lung tissue. It also exhibits selective cytotoxicity in B-cell non-Hodgkin lymphoma compared with normal cells and inhibits production of IL-12 and IL-23. Apilimod dimesylate is also anti-inflammatory and water-soluble.
Hodoodo Cat#: H462765
Name: Apilimod HCl
CAS#: 870087-37-9 (HCl)
Chemical Formula: C23H28Cl2N6O2
Exact Mass: 0.00
Molecular Weight: 491.417
Elemental Analysis: C, 56.22; H, 5.74; Cl, 14.43; N, 17.10; O, 6.51
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 870087-36-8 (mesylate) 541550-19-0 (free base) 1383916-59-3 (free base) 870087-37-9 (HCl) 870151-86-3 (tosylate) 870087-41-5 (besylate)
Synonym: Apilimod HCl; Apilimod hydrochloride; STA-5326; STA5326; STA 5326; LAM-002; LAM 002; LAM002;
IUPAC/Chemical Name: (E)-4-(6-(2-(3-methylbenzylidene)hydrazinyl)-2-(2-(pyridin-2-yl)ethoxy)pyrimidin-4-yl)morpholine dihydrochloride
InChi Key: PJPZEUCDSIGFOW-OKUPSQOASA-N
InChi Code: InChI=1S/C23H26N6O2.2ClH/c1-18-5-4-6-19(15-18)17-25-28-21-16-22(29-10-13-30-14-11-29)27-23(26-21)31-12-8-20-7-2-3-9-24-20;;/h2-7,9,15-17H,8,10-14H2,1H3,(H,26,27,28);2*1H/b25-17+;;
SMILES Code: CC1=CC(/C=N/NC2=CC(N3CCOCC3)=NC(OCCC4=NC=CC=C4)=N2)=CC=C1.[H]Cl.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 491.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
