WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H574789
CAS#: 118427-55-7 (sodium)
Description: MK-886 sodium salt inhibits leukotriene biosynthesis in leukocytes.
Hodoodo Cat#: H574789
Name: MK-886 sodium salt
CAS#: 118427-55-7 (sodium)
Chemical Formula: C27H33ClNNaO2S
Exact Mass: 493.18
Molecular Weight: 494.066
Elemental Analysis: C, 65.64; H, 6.73; Cl, 7.18; N, 2.84; Na, 4.65; O, 6.48; S, 6.49
Related CAS #: 118414-82-7 (free acid) 118427-55-7 (sodium) 1049737-88-3 (sodium hydrate)
Synonym: MK-886 sodium salt
IUPAC/Chemical Name: 1-[(4-chlorophenyl)methyl]-3-[(1,1-dimethylethyl)thio]-α,α-dimethyl-5-(1-methylethyl)-1H-indole-2-propanoic acid, sodium salt
InChi Key: CBNCIYNCWVGEKJ-UHFFFAOYSA-M
InChi Code: InChI=1S/C27H34ClNO2S.Na/c1-17(2)19-10-13-22-21(14-19)24(32-26(3,4)5)23(15-27(6,7)25(30)31)29(22)16-18-8-11-20(28)12-9-18;/h8-14,17H,15-16H2,1-7H3,(H,30,31);/q;+1/p-1
SMILES Code: CC(C)(C([O-])=O)CC1=C(SC(C)(C)C)C2=CC(C(C)C)=CC=C2N1CC3=CC=C(Cl)C=C3.[Na+]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 494.07 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1. Ford-Hutchinson, A.W., Gresser, M., and Young, R.N. 5-Lipoxygenase. Annual Reviews of Biochemistry 63, 383-417 (1994).
2. Abramovitz, M., Wong, E., Cox, M.E., et al. 5-Lipoxygenase-activating protein stimulates the utilization of arachidonic acid by 5-lipoxygenase. European Journal of Biochemistry 215, 105-111 (1993).
3. Dixon, R.A.F., Diehl, R.E., Opas, E., et al. Requirement of a 5-lipoxygenase-activating protein for leukotriene synthesis. Nature 343, 282-284 (1990).
