WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H574858
CAS#: 949912-58-7 (free base)
Description: Remodelin is an inhibitor of N-acetyltransferase 10 (NAT10), which acetylates both histones and microtubules. It improves nuclear shape in HGPS (Hutchinson-Gilford progeria syndrome) cells and lamin A/C depleted cells. Remodelin improves nuclear architecture, chromatin organization, and survival of both cells lacking lamin A and cells from patients with progeria.
Hodoodo Cat#: H574858
Name: Remodelin
CAS#: 949912-58-7 (free base)
Chemical Formula: C15H14N4S
Exact Mass: 282.09
Molecular Weight: 282.360
Elemental Analysis: C, 63.81; H, 5.00; N, 19.84; S, 11.35
Related CAS #: 949912-58-7 (free base) 1622921-15-6 (HBr)
Synonym: Remodelin
IUPAC/Chemical Name: 4-[2-(2-cyclopentylidenehydrazinyl)-4-thiazolyl]-benzonitrile
InChi Key: XAEJIFARBQJLML-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H14N4S/c16-9-11-5-7-12(8-6-11)14-10-20-15(17-14)19-18-13-3-1-2-4-13/h5-8,10H,1-4H2,(H,17,19)
SMILES Code: N#CC1=CC=C(C2=CSC(N/N=C3CCCC\3)=N2)C=C1
Appearance: A crystalline solid
Purity: >95% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO, DMF, and ethanol
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO, DMF, and ethanol
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 282.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1. Larrieu, D., Britton, S., Demir, M., et al. Chemical inhibition of NAT10 corrects defects of laminopathic cells. Science 344(6183), 527-532 (2014).
2. Chimenti, F., Bizzarri, B., Maccioni, E., et al. Synthesis and in vitro activity of 2-thiazolylhydrazone derivatives compared with the activity of clotrimazole against clinical isolates of Candida spp. Bioorganic & Medicinal Chemistry Letters 17(16), 4635-4640 (2007).
