WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H412123
CAS#: 13479-13-5 (free base)
Description: Pargeverine is a therapeutic agent used as premedication when performing endoscopic retrograde cholangiopancreatography (ERCP). Papaverine (Latin papaver, "poppy") is an opium alkaloid antispasmodic drug, used primarily in the treatment of visceral spasm and vasospasm (especially those involving the intestines, heart, or brain), and occasionally in the treatment of erectile dysfunction. It is used in the treatment of acute mesenteric ischemia. While it is found in the opium poppy, papaverine differs in both structure and pharmacological action from the analgesic morphine-like compounds.
Hodoodo Cat#: H412123
Name: Pargeverine
CAS#: 13479-13-5 (free base)
Chemical Formula: C21H23NO3
Exact Mass: 337.17
Molecular Weight: 337.420
Elemental Analysis: C, 74.75; H, 6.87; N, 4.15; O, 14.22
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Related CAS #: 13479-13-5 (free base) 2765-97-1 (HCl)
Synonym: Pargeverine; BE-50; BE50; BE 50
IUPAC/Chemical Name: 2-(Dimethylamino)ethyl diphenyl(2-propynyloxy)acetate
InChi Key: QNPHCSSJLHAKSA-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H23NO3/c1-4-16-25-21(18-11-7-5-8-12-18,19-13-9-6-10-14-19)20(23)24-17-15-22(2)3/h1,5-14H,15-17H2,2-3H3
SMILES Code: O=C(OCCN(C)C)C(C1=CC=CC=C1)(C2=CC=CC=C2)OCC#C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 337.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: de los Santos AR, Martí ML, Di Girolamo G, Diego Espinosa J, Morano MA, Tobar JC, Del Prete C. Propinox in biliary colic: a multicenter, randomized, prospective and parallel double-blind study of three doses of propinox versus placebo in acute biliary colic pain. Int J Tissue React. 1999;21(1):13-8. PubMed PMID: 10463136.
2: Di Girolamo G, de los Santos AR, Martí ML, Valdés Quintana E, Godoy MI, Morano MA, Palomino G, Fandiño D, Greggio A. Propinox in intestinal colic: multicenter randomized prospective double-blind study of three doses of propinox vs. placebo in acute intestinal colic pain. Int J Clin Pharmacol Res. 2000;20(1-2):31-40. PubMed PMID: 11146900.
