WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H412126
CAS#: 1858211-28-5 (hydrate)
Description: Pamiparib, also known as BGB-290, is a highly potent and selective PARP inhibitor with favorable drug metabolism and pharmacokinetic properties. BGB-290 selectively binds to PARP and prevents PARP-mediated repair of single-strand DNA breaks via the base-excision repair (BER) pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability, and eventually leads to apoptosis. BGB-290 may both potentiate the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo- and radioresistance.
Hodoodo Cat#: H412126
Name: Pamiparib hydrate
CAS#: 1858211-28-5 (hydrate)
Chemical Formula: C16H21FN4O4
Exact Mass: 352.15
Molecular Weight: 352.360
Elemental Analysis: C, 54.54; H, 6.01; F, 5.39; N, 15.90; O, 18.16
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 1858211-28-5 (hydrate) 1446261-44-4 (free base) 2243699-99-0 (maleate) 2243700-03-8 (fumarate)
Synonym: Pamiparib hydrate; BGB-290 hydrate; BGB290 hydrate; BGB 290 hydrate
IUPAC/Chemical Name: (2R)-14-fluoro-2-methyl-6,9,10,19-tetrazapentacyclo[14.2.1.02,6.08,18.012,17]nonadeca-1(18),8,12(17),13,15-pentaen-11-one;trihydrate
InChi Key: ZHRNOZDHBOQGIW-UFRNLTNDSA-N
InChi Code: InChI=1S/C16H15FN4O.3H2O/c1-16-3-2-4-21(16)7-11-13-12-9(15(22)20-19-11)5-8(17)6-10(12)18-14(13)16;;;/h5-6,18H,2-4,7H2,1H3,(H,20,22);3*1H2/t16-;;;/m1.../s1
SMILES Code: O=C1NN=C2CN3CCC[C@]3(C)C4=C2C5=C1C=C(F)C=C5N4.[H]O[H].[H]O[H].[H]O[H]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 352.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
