WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H412140
CAS#: 39577-19-0 (free base)
Description: Picumast is an antiasthmatic drug.
Hodoodo Cat#: H412140
Name: Picumast (free base)
CAS#: 39577-19-0 (free base)
Chemical Formula: C25H29ClN2O3
Exact Mass: 440.19
Molecular Weight: 440.960
Elemental Analysis: C, 68.09; H, 6.63; Cl, 8.04; N, 6.35; O, 10.88
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
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Related CAS #: 39577-19-0 (free base) 39577-20-3 (HCl)
Synonym: Picumast; UNII125267OAUF; UNII 125267OAUF; UNII-125267OAUF
IUPAC/Chemical Name: 7-(3-(4-(p-Chlorobenzyl)-1-piperazinyl)propoxy)-3,4-dimethylcoumarin
InChi Key: USCSJAIWXWYTEH-UHFFFAOYSA-N
InChi Code: InChI=1S/C25H29ClN2O3/c1-18-19(2)25(29)31-24-16-22(8-9-23(18)24)30-15-3-10-27-11-13-28(14-12-27)17-20-4-6-21(26)7-5-20/h4-9,16H,3,10-15,17H2,1-2H3
SMILES Code: O=C1OC2=C(C=CC(OCCCN3CCN(CC4=CC=C(Cl)C=C4)CC3)=C2)C(C)=C1C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
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The following data is based on the product molecular weight 440.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Hingorani M, Lightman S. Therapeutic options in ocular allergic disease. Drugs. 1995 Aug;50(2):208-21. doi: 10.2165/00003495-199550020-00002. PMID: 8521755.
2: Wan BY, Peh KH, Assem ES. Effect of picumast on histamine release from rat cardiac and peritoneal mast cells. Agents Actions. 1991 May;33(1-2):71-5. doi: 10.1007/BF01993130. PMID: 1716840.
3: Moqbel R, Hartnell A, Kay AB. The effects of picumast on human eosinophil and neutrophil activation. Clin Exp Allergy. 1991 May;21 Suppl 3:39-44. doi: 10.1111/j.1365-2222.1991.tb01762.x. PMID: 1680539.
4: Rösch A, Schaumann W, Wilhelms OH. Picumast and mast cell function. Clin Exp Allergy. 1991 May;21 Suppl 3:17-22. doi: 10.1111/j.1365-2222.1991.tb01759.x. PMID: 1680538.
5: Wilhelms OH, Roesch A, Schaumann W. Picumast dihydrochloride (Auteral), a new anti-allergic inhibitor of mediator release and action. Agents Actions Suppl. 1991;34:335-49. PMID: 1686528.
6: Besenfelder E. High performance liquid chromatographic determination of Picumast and two active metabolites in plasma using on-line sample preparation. Biomed Chromatogr. 1991 Jan;5(1):32-7. doi: 10.1002/bmc.1130050108. PMID: 1674434.
7: Upton RA. Pharmacokinetic interactions between theophylline and other medication (Part I). Clin Pharmacokinet. 1991 Jan;20(1):66-80. doi: 10.2165/00003088-199120010-00005. PMID: 1674242.
8: Hockwin O, Müller-Breitenkamp U, Laser H, Messinger D, Goder G, Meinel U. Lens safety study with Picumast dihydrochloride--a double masked study using the Scheimpflug method. Lens Eye Toxic Res. 1990;7(3-4):625-30. PMID: 1983108.
9: Boerner D, Metz K, Eberhardt R. Acceptability, safety and efficacy of picumast dihydrochloride on long-term use in patients with perennial bronchial asthma. Arzneimittelforschung. 1989 Oct;39(10A):1372-4. PMID: 2576367.
10: Slapke J, Müller S, Boerner D. A one-year double-blind clinical study of the efficacy and tolerability of picumast dihydrochloride versus ketotifen in patients with bronchial asthma. Arzneimittelforschung. 1989 Oct;39(10A):1368-72. PMID: 2576366.
11: Boerner D, Metz K, Eberhardt R. Efficacy and tolerability of picumast dihydrochloride in comparison with placebo in asthmatic patients. Arzneimittelforschung. 1989 Oct;39(10A):1363-7. PMID: 2576365.
12: Franke W, Messinger D. Double-blind multicenter controlled clinical study comparing the efficacy of picumast dihydrochloride versus astemizole and placebo in patients with seasonal allergic rhinitis. Arzneimittelforschung. 1989 Oct;39(10A):1360-3. PMID: 2576364.
13: Boerner D, Metz K, Eberhardt R, Schürmann W. A placebo-controlled comparison of the efficacy and tolerability of picumast dihydrochloride and terfenadine in patients with seasonal allergic rhinitis. Arzneimittelforschung. 1989 Oct;39(10A):1356-9. PMID: 2576363.
14: Franke W, Bachert C, Messinger D. Double-blind controlled crossover study comparing the protective effect of picumast dihydrochloride versus placebo following nasal allergen challenge. Arzneimittelforschung. 1989 Oct;39(10A):1354-6. PMID: 2576362.
15: Herberg KW. Double-blind study on the influence of picumast dihydrochloride on safety-related performance. Arzneimittelforschung. 1989 Oct;39(10A):1348-51. PMID: 2576361.
16: Neugebauer G, Raedsch R, Stiehl A, Kaufmann B, Besenfelder E, Neubert P, Walter-Sack I. Pharmacokinetics of picumast dihydrochloride in patients with liver cirrhosis. Arzneimittelforschung. 1989 Oct;39(10A):1343-7. PMID: 2576360.
17: Wittenbrink-Dix AM, Neugebauer G, Fuhr U, Neubert P, Besenfelder E, Woelke- Seidl E, Harder S, Staib AH. Study of potential kinetic interactions of picumast dihydrochloride and theophylline in vitro and after oral administration in man. Arzneimittelforschung. 1989 Oct;39(10A):1339-43. PMID: 2576359.
18: Neugebauer G, Wittenbrink-Dix AM, Woelke-Seidl E, Kaufmann B, Ponton T, Dahmen W, Mosberg H, Nieder N, Besenfelder E. Pharmacokinetics of picumast dihydrochloride and its active metabolites M1 and M2 in humans. Arzneimittelforschung. 1989 Oct;39(10A):1336-9. PMID: 2576358.
19: Abraham WM. Effect of picumast dihydrochloride on antigen-induced early and late airway responses in allergic sheep. Arzneimittelforschung. 1989 Oct;39(10A):1328-31. PMID: 2576357.
20: Schaumann W, Besenfelder E, Boehm E, Neubert P, Roesch A, Sterz H. Pharmacokinetics of picumast after administration of 14C-picumast dihydrochloride in dogs, rats, rabbits and monkeys. Arzneimittelforschung. 1989 Oct;39(10A):1321-7. PMID: 2576356.
