WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H574918
CAS#: 143621-35-6 (free base)
Description: Triapine, also known as 3-AP and OCX-191, is a synthetic heterocyclic carboxaldehyde thiosemicarbazone with potential antineoplastic activity. Triapine inhibits the enzyme ribonucleotide reductase, resulting in the inhibition of the conversion of ribonucleoside diphosphates to deoxyribonucleotides necessary for DNA synthesis. This agent has been shown to inhibit tumor growth in vitro.
Hodoodo Cat#: H574918
Name: Triapine free base
CAS#: 143621-35-6 (free base)
Chemical Formula: C7H9N5S
Exact Mass: 195.06
Molecular Weight: 195.240
Elemental Analysis: C, 43.06; H, 4.65; N, 35.87; S, 16.42
Related CAS #: 200933-27-3 (E-isomer) 143621-35-6 (free base) 236392-56-6 (deleted) 216240-62-9 (HCl) 1938041-34-9 (HCl hydrate)
Synonym: 3AP; 3AP; 3Apct; OCX 191; OCX191; OCX191; AIDS179996; AIDS179996; NSC663249. PAN-811; PAN811; PAN 811; Triapine
IUPAC/Chemical Name: (E)-2-((3-aminopyridin-2-yl)methylene)hydrazine-1-carbothioamide
InChi Key: XMYKNCNAZKMVQN-NYYWCZLTSA-N
InChi Code: InChI=1S/C7H9N5S/c8-5-2-1-3-10-6(5)4-11-12-7(9)13/h1-4H,8H2,(H3,9,12,13)/b11-4+
SMILES Code: NC1=C(/C=N/NC(N)=S)N=CC=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 195.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Lin ZP, Zhu YL, Lo YC, Moscarelli J, Xiong A, Korayem Y, Huang PH, Giri S, LoRusso P, Ratner ES. Combination of triapine, olaparib, and cediranib suppresses progression of BRCA-wild type and PARP inhibitor-resistant epithelial ovarian cancer. PLoS One. 2018 Nov 16;13(11):e0207399. doi: 10.1371/journal.pone.0207399. PMID: 30444904; PMCID: PMC6239325.