WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H412450
CAS#: 1211-28-5 (HCl)
Description: Prolintane hydrochloride is the salt from of Prolintane (free base), a stimulant and norepinephrine-dopamine reuptake inhibitor developed in the 1950s. It is the member of amphetamine and derivatives. It is closely related in chemical structure to other drugs such as pyrovalerone, MDPV, and propylhexedrine and it has a similar mechanism of action.
Hodoodo Cat#: H412450
Name: Prolintane hydrochloride
CAS#: 1211-28-5 (HCl)
Chemical Formula: C15H24ClN
Exact Mass: 253.16
Molecular Weight: 253.810
Elemental Analysis: C, 70.98; H, 9.53; Cl, 13.97; N, 5.52
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 493-92-5 (free base) 1211-28-5 (HCl)
Synonym: Prolintane hydrochloride; H246; H-246; H 246
IUPAC/Chemical Name: 1-(1-phenylpentan-2-yl)pyrrolidine hydrochloride
InChi Key: FKOFBBOQSMUYHD-UHFFFAOYSA-N
InChi Code: InChI=1S/C15H23N.ClH/c1-2-8-15(16-11-6-7-12-16)13-14-9-4-3-5-10-14;/h3-5,9-10,15H,2,6-8,11-13H2,1H3;1H
SMILES Code: CCCC(N1CCCC1)Cc2ccccc2.Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 253.81 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Kyle PB, Daley WP. Domestic abuse of the European rave drug prolintane. J Anal Toxicol. 2007 Sep;31(7):415-8. doi: 10.1093/jat/31.7.415. PMID: 17725890.
2: Martínez-Mir I, Catalán C, Palop V. Prolintane: a "masked" amphetamine. Ann Pharmacother. 1997 Feb;31(2):256. doi: 10.1177/106002809703100228. PMID: 9034438.
3: Gaulier JM, Canal M, Pradeille JL, Marquet P, Lachâtre G. Nouvelles drogues de « rave-parties » : ketamine et prolintane. Acta Clin Belg. 2002;57 Suppl 1:41-6. doi: 10.1179/acb.2002.076. PMID: 24862524.
4: Fuller RW, Snoddy HD. Effects of prolintane on 3,4-dihydroxyphenylacetic acid concentration in rat brain after spiperone treatment. Pharmacol Biochem Behav. 1979 Apr;10(4):561-3. doi: 10.1016/0091-3057(79)90233-8. PMID: 572552.
5: Payá B, Guisado JA, Vaz FJ, Crespo-Facorro B. Visual hallucinations induced by the combination of prolintane and diphenhydramine. Pharmacopsychiatry. 2002 Jan;35(1):24-5. doi: 10.1055/s-2002-19829. PMID: 11819155.
6: Souders CL 2nd, Davis RH, Qing H, Liang X, Febo M, Martyniuk CJ. The psychoactive cathinone derivative pyrovalerone alters locomotor activity and decreases dopamine receptor expression in zebrafish (Danio rerio). Brain Behav. 2019 Nov;9(11):e01420. doi: 10.1002/brb3.1420. Epub 2019 Oct 18. PMID: 31625691; PMCID: PMC6851804.
7: Rücker G, Neugebauer M, Zhong D. Synthese einiger Metaboliten und der Enantiomeren des Prolintans [Synthesis of metabolites and enantiomers of prolintane]. Arch Pharm (Weinheim). 1992 Jan;325(1):47-52. German. doi: 10.1002/ardp.19923250111. PMID: 1605711.
8: Gaulier JM, Canal M, Pradeille JL, Marquet P, Lachâtre G. Nouvelles drogues de "rave-parties": Kétamine et Prolintane [New drugs at "rave parties": ketamine and prolintane]. Acta Clin Belg. 2002;57 Suppl 1:41-6. French. PMID: 11974443.
9: Nicholson AN, Stone BM, Jones MM. Wakefullness and reduced rapid eye movement sleep: studies with prolintane and pemoline. Br J Clin Pharmacol. 1980 Nov;10(5):465-72. doi: 10.1111/j.1365-2125.1980.tb01790.x. PMID: 7437258; PMCID: PMC1430138.
10: Espartero AG, Pérez JA, Zapardiel A, Bermejo E, Hernández L. Direct determination of prolintane and its metabolite oxoprolintane in human urine by capillary zone electrophoresis and beta-cyclodextrin-modified micellar electrokinetic chromatography. J Chromatogr A. 1997 Aug 22;778(1-2):355-61. doi: 10.1016/s0021-9673(97)00478-0. PMID: 9299746.
