WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H575059
CAS#: 1354425-86-7
Description: Z-Ascaridole is a biochemical.
Hodoodo Cat#: H575059
Name: Z-Ascaridole
CAS#: 1354425-86-7
Chemical Formula: C10H16O2
Exact Mass: 168.12
Molecular Weight: 168.240
Elemental Analysis: C, 71.39; H, 9.59; O, 19.02
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Related CAS #: 1354425-86-7 512-85-6
Synonym: (+/-)-Ascaridole; (Z)-Ascaridole; Ascarisin; Askaridol; Ascaridole; Ascaridole, (+/-)-; Boldo ascaridole
IUPAC/Chemical Name: (1S,4S)-1-isopropyl-4-methyl-2,3-dioxabicyclo[2.2.2]oct-5-ene
InChi Key: MGYMHQJELJYRQS-ZJUUUORDSA-N
InChi Code: InChI=1S/C10H16O2/c1-8(2)10-6-4-9(3,5-7-10)11-12-10/h4,6,8H,5,7H2,1-3H3/t9-,10+/m1/s1
SMILES Code: CC(C)[C@]12CC[C@@](C)(C=C2)OO1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 168.24 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Geroldinger G, Tonner M, Hettegger H, Bacher M, Monzote L, Walter M, Staniek K, Rosenau T, Gille L. Mechanism of ascaridole activation in Leishmania. Biochem Pharmacol. 2017 May 15;132:48-62. doi: 10.1016/j.bcp.2017.02.023. Epub 2017 Mar 2. PMID: 28263719.
2. Monzote L, Geroldinger G, Tonner M, Scull R, De Sarkar S, Bergmann S, Bacher M, Staniek K, Chatterjee M, Rosenau T, Gille L. Interaction of ascaridole, carvacrol, and caryophyllene oxide from essential oil of Chenopodium ambrosioides L. with mitochondria in Leishmania and other eukaryotes. Phytother Res. 2018 Sep;32(9):1729-1740. doi: 10.1002/ptr.6097. Epub 2018 Apr 19. PMID: 29672979; PMCID: PMC6208284.
3. Sahli F, Sousa MSE, Vileno B, Lichter J, Lepoittevin JP, Blömeke B, Giménez-Arnau E. Understanding the skin sensitization capacity of ascaridole: a combined study of chemical reactivity and activation of the innate immune system (dendritic cells) in the epidermal environment. Arch Toxicol. 2019 May;93(5):1337-1347. doi: 10.1007/s00204-019-02444-3. Epub 2019 Apr 16. PMID: 30993377.