WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H412460
CAS#: 1628078-14-7 (R-isomer)
Description: Mitoglitazone R-isomer is the R-isomer of Mitoglitazone, which is also known as CAY10415. Mitoglitazone is a novel peroxisome proliferator-activated receptor (PPAR)γ ligand. CAY10415 induced cell death and ROS generation in a PPARγ-independent manner. CAY10415 enhanced γ-radiation-induced apoptosis and caspase-3-mediated poly (ADP-ribose) polymerase (PARP) cleavage in vitro. The combined CAY10415 / γ-radiation treatment triggered caspase-8 activation, and this initiator caspase played an important role in the combination-induced apoptosis. The combined treatment of CAY10415 and γ-radiation synergistically induced DNA damage and apoptosis, which was regulated by ROS.
Hodoodo Cat#: H412460
Name: Mitoglitazone R-isomer
CAS#: 1628078-14-7 (R-isomer)
Chemical Formula: C19H18N2O4S
Exact Mass: 370.10
Molecular Weight: 370.420
Elemental Analysis: C, 61.61; H, 4.90; N, 7.56; O, 17.28; S, 8.65
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Related CAS #: 1628078-14-7 (R-isomer) 146062-49-9 (racemic) 1628078-13-6 (S-isomer),
Synonym: Mitoglitazone R-isomer; CAY10415 R-isomer; CAY-10415 R-isomer; CAY 10415 R-isomer;
IUPAC/Chemical Name: (R)-5-(4-(2-(5-ethylpyridin-2-yl)-2-oxoethoxy)benzyl)thiazolidine-2,4-dione
InChi Key: IRNJSRAGRIZIHD-QGZVFWFLSA-N
InChi Code: InChI=1S/C19H18N2O4S/c1-2-12-5-8-15(20-10-12)16(22)11-25-14-6-3-13(4-7-14)9-17-18(23)21-19(24)26-17/h3-8,10,17H,2,9,11H2,1H3,(H,21,23,24)/t17-/m1/s1
SMILES Code: O=C(N1)S[C@H](CC2=CC=C(OCC(C3=NC=C(CC)C=C3)=O)C=C2)C1=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 370.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Björklund E, Norén E, Nilsson J, Fowler CJ. Inhibition of monoacylglycerol lipase by troglitazone, N-arachidonoyl dopamine and the irreversible inhibitor JZL184: comparison of two different assays. Br J Pharmacol. 2010 Dec;161(7):1512-26. doi: 10.1111/j.1476-5381.2010.00974.x. PMID: 20735405; PMCID: PMC3010564.
2: Gu X, Jiang D, Yang Y, Zhang P, Wan G, Gu W, Shi J, Jiang L, Chen B, Zheng Y, Liu D, Guo S, Lu C. Construction and Comprehensive Analysis of Dysregulated Long Noncoding RNA-Associated Competing Endogenous RNA Network in Moyamoya Disease. Comput Math Methods Med. 2020 Jun 13;2020:2018214. doi: 10.1155/2020/2018214. PMID: 32617116; PMCID: PMC7306867.