WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H412549
CAS#: 9004-70-0
Description: Pyroxylin is a nitrocellulose solution in ether and alcohol. Collodion has a wide range of uses in industry including applications in the manufacture of photographic film, in fibers, in lacquers, and in engraving and lithography. In medicine it is used as a drug solvent and a wound sealant.
Hodoodo Cat#: H412549
Name: Pyroxylin
CAS#: 9004-70-0
Chemical Formula: C18H21N11O38
Exact Mass: 999.00
Molecular Weight: 999.410
Elemental Analysis: C, 21.63; H, 2.12; N, 15.42; O, 60.83
Synonym: Pyroxylin; LR115; LR-115; LR 115
IUPAC/Chemical Name: [(2S,3R,4S,5R,6R)-2-[(2R,3R,4S,5R,6S)-4,5-dinitrooxy-2-(nitrooxymethyl)-6-[(2R,3R,4S,5R,6S)-4,5,6-trinitrooxy-2-(nitrooxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-3,5-dinitrooxy-6-(nitrooxymethyl)oxan-4-yl] nitrate
InChi Key: FJWGYAHXMCUOOM-QHOUIDNNSA-N
InChi Code: InChI=1S/C18H21N11O38/c30-19(31)52-1-4-7(58-17-14(65-27(46)47)12(63-25(42)43)9(60-22(36)37)6(56-17)3-54-21(34)35)10(61-23(38)39)13(64-26(44)45)16(55-4)59-8-5(2-53-20(32)33)57-18(67-29(50)51)15(66-28(48)49)11(8)62-24(40)41/h4-18H,1-3H2/t4-,5-,6-,7-,8-,9-,10+,11+,12+,13-,14-,15-,16+,17+,18+/m1/s1
SMILES Code: O=[N+]([O-])O[C@@H]1[C@@H](O[N+]([O-])=O)[C@H](O[C@@H]2[C@@H](CO[N+]([O-])=O)O[C@@H](O[C@@H]3[C@@H](CO[N+]([O-])=O)O[C@@H](O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]3O[N+]([O-])=O)[C@H](O[N+]([O-])=O)[C@H]2O[N+]([O-])=O)O[C@H](CO[N+]([O-])=O)[C@H]1O[N+]([O-])=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 999.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Kurien BT, Scofield RH. Western blotting. Methods. 2006 Apr;38(4):283-93. doi: 10.1016/j.ymeth.2005.11.007. PMID: 16483794.
2: Lee PY, Osman J, Low TY, Jamal R. Plasma/serum proteomics: depletion strategies for reducing high-abundance proteins for biomarker discovery. Bioanalysis. 2019 Oct;11(19):1799-1812. doi: 10.4155/bio-2019-0145. Epub 2019 Oct 16. PMID: 31617391.
3: Fiume MM, Bergfeld WF, Belsito DV, Hill RA, Klaassen CD, Liebler DC, Marks JG Jr, Shank RC, Slaga TJ, Snyder PW, Andersen FA. Safety Assessment of Nitrocellulose and Collodion as Used in Cosmetics. Int J Toxicol. 2016 Jul;35(1 Suppl):50S-9S. doi: 10.1177/1091581816651607. PMID: 27383197.
4: Greenfield EA. Immunizing Mice and Rats with Nitrocellulose-Bound Antigen. Cold Spring Harb Protoc. 2019 Dec 2;2019(12). doi: 10.1101/pdb.prot100248. PMID: 31792142.
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6: Kolitz S, Lorsch JR. Protein filter binding. Methods Enzymol. 2014;541:197-205. doi: 10.1016/B978-0-12-420119-4.00016-1. PMID: 24674073.
7: Surendran S, Mathai A, Radhakrishnan VV. Dot-immunobinding assay (Dot-Iba). Methods Mol Biol. 2015;1312:105-8. doi: 10.1007/978-1-4939-2694-7_14. PMID: 26043995.
8: Mazitova NN, Amirov NKh, Berkheeva ZM. Obosnovanie kriticheskogo stazha raboty i kriteriev ranneĭ diagnostiki professional'noĭ i professional'no obuslovlennoĭ patologii u rabotaiushchikh v proizvodstve piroksilinovogo porokha [Bases of critical length of service and criteria of early diagnosis of occupational diseases in workers of pyroxylin powder production]. Med Tr Prom Ekol. 1996;(10):10-5. Russian. PMID: 9064094.
9: Chi J, Gao B, Sun M, Zhang F, Su E, Liu H, Gu Z. Patterned Photonic Nitrocellulose for Pseudopaper ELISA. Anal Chem. 2017 Jul 18;89(14):7727-7733. doi: 10.1021/acs.analchem.7b01732. Epub 2017 Jun 27. PMID: 28622470.
10: Lowe G. Slice blotting. Methods Mol Biol. 2015;1312:87-92. doi: 10.1007/978-1-4939-2694-7_12. PMID: 26043993.
