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Desmopressin acetate
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WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H413260

CAS#: 62288-83-9 (acetate)

Description: Desmopressin acetate is a synthetic analog of the pituitary hormone, ARGININE VASOPRESSIN. Its action is mediated by the VASOPRESSIN receptor V2. It has prolonged antidiuretic activity, but little pressor effects. It also modulates levels of circulating FACTOR VIII and VON WILLEBRAND FACTOR.

Chemical Structure

Desmopressin acetate

CAS# 62288-83-9 (acetate)

Instruction

Theoretical Analysis

Hodoodo Cat#: H413260
Name: Desmopressin acetate
CAS#: 62288-83-9 (acetate)
Chemical Formula: C48H68N14O14S2
Exact Mass: 1,128.45
Molecular Weight: 1,129.280
Elemental Analysis: C, 51.05; H, 6.07; N, 17.36; O, 19.83; S, 5.68

Price and Availability

Size	Price	Availability
10mg	USD 362	2 Weeks
25mg	USD 600	2 Weeks
50mg	USD 915	2 Weeks
100mg	USD 1345	2 Weeks
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. Hodoodo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: Octostim; Desmopressin acetate; Noctiva; Minirin; Stimate

IUPAC/Chemical Name: (S)-1-((4R,7S,10S,13S,16S)-7-(2-amino-2-oxoethyl)-10-(3-amino-3-oxopropyl)-13-benzyl-16-(4-hydroxybenzyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentaazacycloicosane-4-carbonyl)-N-((R)-1-((2-amino-2-oxoethyl)amino)-5-guanidino-1-oxopentan-2-yl)pyrrolidine-2-carboxamide acetate

InChi Key: MLSVJHOYXJGGTR-IFHOVBQLSA-N

InChi Code: InChI=1S/C46H64N14O12S2.C2H4O2/c47-35(62)15-14-29-40(67)58-32(22-36(48)63)43(70)59-33(45(72)60-18-5-9-34(60)44(71)56-28(8-4-17-52-46(50)51)39(66)53-23-37(49)64)24-74-73-19-16-38(65)54-30(21-26-10-12-27(61)13-11-26)41(68)57-31(42(69)55-29)20-25-6-2-1-3-7-25;1-2(3)4/h1-3,6-7,10-13,28-34,61H,4-5,8-9,14-24H2,(H2,47,62)(H2,48,63)(H2,49,64)(H,53,66)(H,54,65)(H,55,69)(H,56,71)(H,57,68)(H,58,67)(H,59,70)(H4,50,51,52);1H3,(H,3,4)/t28-,29+,30+,31+,32+,33+,34+;/m1./s1

SMILES Code: CC(O)=O.NC(CC[C@@H]1NC([C@@H](NC([C@@H](NC(CCSSC[C@@H](C(N2CCC[C@H]2C(N[C@@H](C(NCC(N)=O)=O)CCCNC(N)=N)=O)=O)NC([C@@H](NC1=O)CC(N)=O)=O)=O)Cc3ccc(O)cc3)=O)Cc4ccccc4)=O)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	Soluble in DMSO	0.0	100.00

Preparing Stock Solutions

The following data is based on the product molecular weight 1,129.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Alford N, Hashim H. Desmopressin acetate the first sublingual tablet to treat nocturia due to nocturnal polyuria. Expert Rev Clin Pharmacol. 2021 Aug;14(8):939-954. doi: 10.1080/17512433.2021.1931122. Epub 2021 Jun 14. PMID: 33993824.

2: Cohn JA, Kowalik CG, Reynolds WS, Kaufman MR, Milam DF, Dmochowski RR, Wein AJ. Desmopressin acetate nasal spray for adults with nocturia. Expert Rev Clin Pharmacol. 2017 Dec;10(12):1281-1293. doi: 10.1080/17512433.2017.1394185. Epub 2017 Oct 30. PMID: 29048257.

3: Karanth L, Barua A, Kanagasabai S, Nair NS. Desmopressin acetate (DDAVP) for preventing and treating acute bleeds during pregnancy in women with congenital bleeding disorders. Cochrane Database Syst Rev. 2013 Apr 30;(4):CD009824. doi: 10.1002/14651858.CD009824.pub2. Update in: Cochrane Database Syst Rev. 2015;(9):CD009824. PMID: 23633378.

4: Karanth L, Barua A, Kanagasabai S, Nair S. Desmopressin acetate (DDAVP) for preventing and treating acute bleeds during pregnancy in women with congenital bleeding disorders. Cochrane Database Syst Rev. 2015 Sep 9;(9):CD009824. doi: 10.1002/14651858.CD009824.pub3. Update in: Cochrane Database Syst Rev. 2019 Feb 13;2:CD009824. PMID: 26350784.

5: Wang Q, Alshayyah R, Yang B. The efficacy and safety of desmopressin acetate applied for nocturia in benign prostatic hyperplasia patients: A systematic review and meta-analysis. Low Urin Tract Symptoms. 2022 May;14(3):155-162. doi: 10.1111/luts.12423. Epub 2022 Jan 16. PMID: 35034423.

6: Moffatt ME, Harlos S, Kirshen AJ, Burd L. Desmopressin acetate and nocturnal enuresis: how much do we know? Pediatrics. 1993 Sep;92(3):420-5. PMID: 8361796.

7: Galati P, Archer T, Jolly R, Sullivant A, Wills R, Lathan P. Effects of desmopressin acetate administration in healthy dogs receiving prednisolone. J Vet Intern Med. 2021 Sep;35(5):2271-2276. doi: 10.1111/jvim.16250. Epub 2021 Aug 27. PMID: 34448503; PMCID: PMC8478070.

8: Sattari SA, Shahoori A, Shahbazian H, Sabetnia L, Aref A, Sattari AR, Ghorbani A. Desmopressin Acetate in Percutaneous Ultrasound-Guided Native Kidney Biopsy in Patients with Reduced Kidney Function: A Double-Blind Randomized Controlled Trial. Iran J Kidney Dis. 2022 Jul;16(4):238-245. PMID: 35962638.

9: Richardson DW, Robinson AG. Desmopressin. Ann Intern Med. 1985 Aug;103(2):228-39. doi: 10.7326/0003-4819-103-2-228. PMID: 3893256.

10: Lim CC, Tan HZ, Tan CS, Healy H, Choo J, Franca Gois PH. Desmopressin acetate to prevent bleeding in percutaneous kidney biopsy: a systematic review. Intern Med J. 2021 Apr;51(4):571-579. doi: 10.1111/imj.14774. PMID: 32040251.

11: Kasper CK. Desmopressin acetate (DDAVP). Good news. JAMA. 1984 May 18;251(19):2564-5. PMID: 6609247.

12: Wang LC, Hu YF, Chen L, Xing R, Lin XF, Kou QY. Desmopressin acetate decreases blood loss in patients with massive hemorrhage undergoing gastrointestinal surgery. Turk J Gastroenterol. 2020 Jun;31(6):474-481. doi: 10.5152/tjg.2020.19021. PMID: 32721919; PMCID: PMC7433999.

13: Temeck BK, Bachenheimer LC, Katz NM, Coughlin SS, Wallace RB. Desmopressin acetate in cardiac surgery: a double-blind, randomized study. South Med J. 1994 Jun;87(6):611-5. doi: 10.1097/00007611-199406000-00006. PMID: 8202769.

14: McManus J, Ferreira J, Jones GM, Smetana KS, Smith Condeni M, Berger K, Witenko C, Smotherman C, Gautam S, Pizzi MA, Erdman MJ. Effect of desmopressin acetate on acute spontaneous intracranial hemorrhage in patients on antiplatelet therapy. J Neurol Sci. 2022 Mar 15;434:120142. doi: 10.1016/j.jns.2022.120142. Epub 2022 Jan 6. PMID: 35081458.

15: Hayashi M. [Pharmacological and clinical profile of desmopressin acetate hydrate (MINIRIN Melt(®))]. Nihon Yakurigaku Zasshi. 2013 Mar;141(3):169-74. Japanese. doi: 10.1254/fpj.141.169. PMID: 23470483.

16: Vance DA. Desmopressin acetate. J Post Anesth Nurs. 1988 Feb;3(1):65-6. PMID: 3351781.

17: Manno C, Bonifati C, Torres DD, Campobasso N, Schena FP. Desmopressin acetate in percutaneous ultrasound-guided kidney biopsy: a randomized controlled trial. Am J Kidney Dis. 2011 Jun;57(6):850-5. doi: 10.1053/j.ajkd.2010.12.019. Epub 2011 Feb 26. PMID: 21354681.

18: Smith RC. Desmopressin acetate in postoperative bleeding. DICP. 1990 May;24(5):475-6. PMID: 2188433.

19: David JL. Desmopressin and hemostasis. Regul Pept. 1993 Apr 29;45(1-2):311-7. doi: 10.1016/0167-0115(93)90227-y. PMID: 8511363.

20: Mansouritorghabeh H, Shirdel A. Desmopressin acetate as a haemostatic elevator in individuals with combined deficiency of factors V and VIII: a clinical trial. J Thromb Haemost. 2016 Feb;14(2):336-9. doi: 10.1111/jth.13207. Epub 2016 Jan 30. PMID: 26599105.

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