WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H412604
CAS#: 83881-51-0 (free base)
Description: Cetirizine (free base) is a potent second-generation histamine H1 antagonist that is effective in the treatment of allergic rhinitis, chronic urticaria, and pollen-induced asthma. Unlike many traditional antihistamines, it does not cause drowsiness or anticholinergic side effects.
Hodoodo Cat#: H412604
Name: Cetirizine (free base)
CAS#: 83881-51-0 (free base)
Chemical Formula: C21H25ClN2O3
Exact Mass: 388.16
Molecular Weight: 388.890
Elemental Analysis: C, 64.86; H, 6.48; Cl, 9.12; N, 7.20; O, 12.34
Related CAS #: 83881-51-0 (free base) 83881-52-1 (HCl)
Synonym: Cetirizine (free base); AC170; AC 170 AC-170
IUPAC/Chemical Name: Acetic acid, (2-(4-((4-chlorophenyl)phenylmethyl)-1-piperazinyl)ethoxy)-
InChi Key: ZKLPARSLTMPFCP-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H25ClN2O3/c22-19-8-6-18(7-9-19)21(17-4-2-1-3-5-17)24-12-10-23(11-13-24)14-15-27-16-20(25)26/h1-9,21H,10-16H2,(H,25,26)
SMILES Code: O=C(O)COCCN1CCN(C(C2=CC=C(Cl)C=C2)C3=CC=CC=C3)CC1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >3 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 388.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Ekstrand C, Ingvast-Larsson C, Bondesson U, Hedeland M, Olsén L. Cetirizine per os: exposure and antihistamine effect in the dog. Acta Vet Scand. 2018 Nov 26;60(1):77. doi: 10.1186/s13028-018-0431-3. PMID: 30477556; PMCID: PMC6258303.
2: Nayak AS, Berger WE, LaForce CF, Urdaneta ER, Patel MK, Franklin KB, Wu MM. Randomized, placebo-controlled study of cetirizine and loratadine in children with seasonal allergic rhinitis. Allergy Asthma Proc. 2017 May 1;38(3):222-230. doi: 10.2500/aap.2017.38.4050. PMID: 28441993.
3: Rossi A, Campo D, Fortuna MC, Garelli V, Pranteda G, De Vita G, Sorriso-Valvo L, Di Nunno D, Carlesimo M. A preliminary study on topical cetirizine in the therapeutic management of androgenetic alopecia. J Dermatolog Treat. 2018 Mar;29(2):149-151. doi: 10.1080/09546634.2017.1341610. Epub 2017 Jun 29. PMID: 28604133.
4: Groschner K, Pöch G. Cetirizin [Cetirizine]. Dtsch Med Wochenschr. 1998 Dec 11;123(50):1523-4. German. doi: 10.1055/s-0029-1237295. PMID: 9879282.
5: Chen C. Physicochemical, pharmacological and pharmacokinetic properties of the zwitterionic antihistamines cetirizine and levocetirizine. Curr Med Chem. 2008;15(21):2173-91. doi: 10.2174/092986708785747625. PMID: 18781943.
6: Knych HK, Weiner D, Steinmetz S, Flynn K, McKemie DS. Pharmacokinetics of hydroxyzine and cetirizine following oral administration of hydroxyzine to exercised Thoroughbred horses. J Vet Pharmacol Ther. 2019 Nov;42(6):617-623. doi: 10.1111/jvp.12808. Epub 2019 Sep 6. PMID: 31490561.
7: Sedivý J. Cetirizin [Cetirizine]. Cesk Pediatr. 1993 Dec;48(12):729. Czech. PMID: 8137448.
8: Zhang L, Cheng L, Hong J. The clinical use of cetirizine in the treatment of allergic rhinitis. Pharmacology. 2013;92(1-2):14-25. doi: 10.1159/000351843. Epub 2013 Jul 18. PMID: 23867423.
9: Rutkowski K, Wagner A. Cetirizine anaphylaxis. Ann Allergy Asthma Immunol. 2014 Sep;113(3):247-9. doi: 10.1016/j.anai.2014.06.030. PMID: 25168222.
10: Abdelmaksoud A. Topical cetirizine 1% for treatment of androgenetic alopecia. Dermatol Ther. 2017 Nov;30(6). doi: 10.1111/dth.12530. Epub 2017 Aug 10. PMID: 28796428.
