WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H412847
CAS#: 101-40-6 (free base)
Description: Propylhexedrine (free base) is an alpha-adrenergic stimulant used extensively in nasal decongestant inhalers.
Hodoodo Cat#: H412847
Name: Propylhexedrine (free base)
CAS#: 101-40-6 (free base)
Chemical Formula: C10H21N
Exact Mass: 155.17
Molecular Weight: 155.290
Elemental Analysis: C, 77.35; H, 13.63; N, 9.02
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Related CAS #: 1007-33-6 (HCl) 101-40-6 (free base)
Synonym: Propylhexedrine; NSC32410; NSC-32410; NSC 32410
IUPAC/Chemical Name: 1-cyclohexyl-N-methylpropan-2-amine
InChi Key: JCRIVQIOJSSCQD-UHFFFAOYSA-N
InChi Code: InChI=1S/C10H21N/c1-9(11-2)8-10-6-4-3-5-7-10/h9-11H,3-8H2,1-2H3
SMILES Code: CNC(CC1CCCCC1)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 155.29 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
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2: Wesson DR. Propylhexdrine. Drug Alcohol Depend. 1986 Jun;17(2-3):273-8. doi: 10.1016/0376-8716(86)90013-x. PMID: 2874970.
3: Croft CH, Firth BG, Hillis LD. Propylhexedrine-induced left ventricular dysfunction. Ann Intern Med. 1982 Oct;97(4):560-1. doi: 10.7326/0003-4819-97-4-560. PMID: 6127046.
4: Iven H, Feldbusch E. Pharmacokinetics of phenobarbital and propylhexedrine after administration of barbexaclone in the mouse. Naunyn Schmiedebergs Arch Pharmacol. 1983 Sep;324(2):153-9. doi: 10.1007/BF00497022. PMID: 6139756.
5: Anderson ED. Propylhexedrine (Benzedrex) psychosis. N Z Med J. 1970 May;71(456):302. PMID: 5270979.
6: Riddick L, Reisch R. Oral overdose of propylhexedrine. J Forensic Sci. 1981 Oct;26(4):834-9. PMID: 6117600.
7: White L, DiMaio VJ. Intravenous propylhexedrine and sudden death. N Engl J Med. 1977 Nov 10;297(19):1071. doi: 10.1056/nejm197711102971920. PMID: 20578.
8: Hamilton LH. Nasal decongestant effect of propylhexedrine. Ann Otol Rhinol Laryngol. 1982 Jan-Feb;91(1 Pt 1):106-11. doi: 10.1177/000348948209100124. PMID: 6176171.
9: Appel W, Sprengard D. Zur Pharmakokinetik von Propylhexedrine [Pharmacokinetics of propylhexedrine]. Arzneimittelforschung. 1971 Jun;21(6):894-9. German. PMID: 5109288.
10: Holler JM, Vorce SP, McDonough-Bender PC, Magluilo J Jr, Solomon CJ, Levine B. A drug toxicity death involving propylhexedrine and mitragynine. J Anal Toxicol. 2011 Jan;35(1):54-9. doi: 10.1093/anatox/35.1.54. PMID: 21219704.