WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H535868
CAS#: 491872-39-0 (acetate)
Description: Rapastinel, also known as GLYX-13 and BV-102, is a novel antidepressant drug approved as an adjunctive therapy for the treatment of treatment-resistant major depressive disorder. It is a centrally active, intravenously administered (non-orally active) amidated tetrapeptide (Thr-Pro-Pro-Thr-NH2) that acts as a selective, weak partial agonist (mixed antagonist/agonist) of an allosteric site at the glycine site of the NMDA receptor complex (Emax ≈ 25%).[1][2] The drug is a rapid-acting and long-lasting antidepressant as well as robust cognitive enhancer by virtue of its ability to both inhibit and enhance NMDA receptor-mediated signal transduction.
Hodoodo Cat#: H535868
Name: Rapastinel acetate
CAS#: 491872-39-0 (acetate)
Chemical Formula: C20H35N5O8
Exact Mass: 473.25
Molecular Weight: 473.527
Elemental Analysis: C, 50.73; H, 7.45; N, 14.79; O, 27.03
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 491872-39-0 (acetate) 117928-94-6 (free base)
Synonym: Rapastinel acetate; GLYX-13; GLYX 13; GLYX13; BV-102; BV102; BV 102; TPPT-amide;
IUPAC/Chemical Name: L-Threoninamide, L-threonyl-L-prolyl-L-prolyl-, monoacetate
InChi Key: MNEQLJKNUQMKNP-GDLIIDCZSA-N
InChi Code: InChI=1S/C18H31N5O6.C2H4O2/c1-9(24)13(19)18(29)23-8-4-6-12(23)17(28)22-7-3-5-11(22)16(27)21-14(10(2)25)15(20)26;1-2(3)4/h9-14,24-25H,3-8,19H2,1-2H3,(H2,20,26)(H,21,27);1H3,(H,3,4)/t9-,10-,11+,12+,13+,14+;/m1./s1
SMILES Code: C[C@@H](O)[C@@H](C(N)=O)NC([C@H]1N(C([C@H]2N(C([C@H]([C@H](O)C)N)=O)CCC2)=O)CCC1)=O.CC(O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| Soluble in DMSO | 0.0 | 100.00 |
The following data is based on the product molecular weight 473.53 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
