BD 1008 Free Base
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Hodoodo CAT#: H413526

CAS#: 138356-08-8 (free base)

Description: BD 1008 Free Base is a selective sigma receptor antagonist, with a reported binding affinity of Kᵢ = 2 ± 1 nM for the sigma-1 receptor and 4 times selectivity over the sigma-2 receptor.

Chemical Structure

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BD 1008 Free Base
CAS# 138356-08-8 (free base)
Instruction

Theoretical Analysis

Hodoodo Cat#: H413526
Name: BD 1008 Free Base
CAS#: 138356-08-8 (free base)
Chemical Formula: C15H22Cl2N2
Exact Mass: 300.12
Molecular Weight: 301.260
Elemental Analysis: C, 59.80; H, 7.36; Cl, 23.53; N, 9.30

Price and Availability

Size Price Availability Quantity
10mg USD 380 2 Weeks
50mg USD 815 2 Weeks
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Related CAS #: 138356-08-8 (free base)   138356-09-9 (HBr)  

Synonym: BD 1008 Free Base; BD1008; BD-1008

IUPAC/Chemical Name: 1-Pyrrolidineethanamine, N-(2-(3,4-dichlorophenyl)ethyl)-N-methyl-

InChi Key: ASGIQUHBAVIOTI-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H22Cl2N2/c1-18(10-11-19-7-2-3-8-19)9-6-13-4-5-14(16)15(17)12-13/h4-5,12H,2-3,6-11H2,1H3

SMILES Code: CN(CCC1=CC=C(Cl)C(Cl)=C1)CCN2CCCC2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Solubility Data

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
To be determined 0.0 0.00

Preparing Stock Solutions

The following data is based on the product molecular weight 301.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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6: Hiranita T, Soto PL, Kohut SJ, Kopajtic T, Cao J, Newman AH, Tanda G, Katz JL. Decreases in cocaine self-administration with dual inhibition of the dopamine transporter and σ receptors. J Pharmacol Exp Ther. 2011 Nov;339(2):662-77. doi: 10.1124/jpet.111.185025. Epub 2011 Aug 22. PMID: 21859929; PMCID: PMC3199989.

7: Hudzik TJ, De Costa BR, McMillan DE. Sigma receptor-mediated emetic response in pigeons: agonists, antagonists and modifiers. Eur J Pharmacol. 1993 May 19;236(2):279-87. doi: 10.1016/0014-2999(93)90599-d. PMID: 8100532.

8: Beninger RJ. International Behavioral Neuroscience Society - Ninth meeting. Neurochemistry of feeding. IDrugs. 2000 Jul;3(7):745-6. PMID: 16080042.

9: Couture S, Debonnel G. Modulation of the neuronal response to N-methyl-D- aspartate by selective sigma2 ligands. Synapse. 1998 May;29(1):62-71. doi: 10.1002/(SICI)1098-2396(199805)29:1<62::AID-SYN5>3.0.CO;2-9. PMID: 9552175.

10: Berardi F, Ferorelli S, Colabufo NA, Leopoldo M, Perrone R, Tortorella V. A multireceptorial binding reinvestigation on an extended class of sigma ligands: N-[omega-(indan-1-yl and tetralin-1-yl)alkyl] derivatives of 3,3-dimethylpiperidine reveal high affinities towards sigma1 and EBP sites. Bioorg Med Chem. 2001 May;9(5):1325-35. doi: 10.1016/s0968-0896(01)00011-6. PMID: 11377189.