WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H413556
CAS#: 78273-80-0 (free base)
Description: Roxatidine Free Base is a TZU 0460 active metabolite.
Hodoodo Cat#: H413556
Name: Roxatidine Free Base
CAS#: 78273-80-0 (free base)
Chemical Formula: C17H26N2O3
Exact Mass: 306.19
Molecular Weight: 306.406
Elemental Analysis: C, 66.64; H, 8.55; N, 9.14; O, 15.66
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 78273-80-0 (free base) 93793-83-0 (Acetate Hydrochloride) 78628-28-1 (roxatidine acetate)
Synonym: Roxatidine Free Base; Desacetyl-tzu-0460
IUPAC/Chemical Name: Acetamide, 2-hydroxy-N-(3-(3-(1-piperidinylmethyl)phenoxy)propyl)-
InChi Key: BCCREUFCSIMJFS-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H26N2O3/c20-14-17(21)18-8-5-11-22-16-7-4-6-15(12-16)13-19-9-2-1-3-10-19/h4,6-7,12,20H,1-3,5,8-11,13-14H2,(H,18,21)
SMILES Code: O=C(NCCCOC1=CC=CC(CN2CCCCC2)=C1)CO
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 306.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Ze R, Wang S, Xie M, Zhang B, Tang X, Li J. Roxatidine Attenuates Degradation of Extracellular Matrix. Biomed Pharmacother. 2017 Nov;95:1156-1160. doi: 10.1016/j.biopha.2017.08.130. Epub 2017 Sep 15. PMID: 28926925.
2: Ji L, Wang T, Tian L, Song H, Gao M. Roxatidine inhibits fibrosis by inhibiting NF‑κB and MAPK signaling in macrophages sensing breast implant surface materials. Mol Med Rep. 2020 Jan;21(1):161-172. doi: 10.3892/mmr.2019.10815. Epub 2019 Nov 12. PMID: 31746427; PMCID: PMC6896367.
3: Lee M, Lee NY, Chung KS, Cheon SY, Lee KT, An HJ. Roxatidine attenuates mast cell-mediated allergic inflammation via inhibition of NF-κB and p38 MAPK activation. Sci Rep. 2017 Jan 31;7:41721. doi: 10.1038/srep41721. PMID: 28139747; PMCID: PMC5282503.
4: Murdoch D, McTavish D. Roxatidine acetate. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic potential in peptic ulcer disease and related disorders. Drugs. 1991 Aug;42(2):240-60. doi: 10.2165/00003495-199142020-00006. PMID: 1717223.
5: Dammann HG, de Looze SM, Bender W, Labs R. Clinical characteristics of roxatidine acetate: a review. Scand J Gastroenterol Suppl. 1988;146:121-34. doi: 10.3109/00365528809099138. PMID: 2906456.
6: Scholtholt J, Bickel M, Herling AW. A review of the animal pharmacology of roxatidine acetate. Drugs. 1988;35 Suppl 3:30-40. doi: 10.2165/00003495-198800353-00008. PMID: 2905247.
7: Habibullah CM, Habeeb MA, Singh SP. Roxatidine in duodenal ulcer. J Postgrad Med. 1995 Jul-Sep;41(3):64-5. PMID: 10707717.
8: Agrawal SS, Alvin Jose M. Roxatidine, an H(2) receptor blocker, is an estrogenic compound--experimental evidence. Syst Biol Reprod Med. 2010 Aug;56(4):286-91. doi: 10.3109/19396368.2010.496894. PMID: 20718616.
9: Cho EJ, An HJ, Shin JS, Choi HE, Ko J, Cho YW, Kim HM, Choi JH, Lee KT. Roxatidine suppresses inflammatory responses via inhibition of NF-κB and p38 MAPK activation in LPS-induced RAW 264.7 macrophages. J Cell Biochem. 2011 Dec;112(12):3648-59. doi: 10.1002/jcb.23294. PMID: 21809375.
10: Fock KM, Kang JY, Ng HS, Ng TM, Gwee KA, Lim CC. Roxatidine versus ranitidine in the treatment of duodenal ulcers: a randomized double-blind controlled multicentre study in Singapore. J Gastroenterol Hepatol. 1995 Jul- Aug;10(4):379-82. doi: 10.1111/j.1440-1746.1995.tb01587.x. PMID: 8527701.
