WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H413584
CAS#: 93414-04-1 (fumarate)
Description: Desvenlafaxine fumarate is used to treat depression. It may improve your mood, feelings of well-being, and energy level. Desvenlafaxine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). It works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.
Hodoodo Cat#: H413584
Name: Desvenlafaxine fumarate
CAS#: 93414-04-1 (fumarate)
Chemical Formula: C20H29NO6
Exact Mass: 0.00
Molecular Weight: 379.450
Elemental Analysis: C, 63.31; H, 7.70; N, 3.69; O, 25.30
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 93413-62-8 (free base) 448904-47-0 (succinate) 386750-22-7 (Succinate hydrate) 300827-87-6 (HCl) 93414-04-1 (fumarate) 1147940-37-1 (benzoate),
Synonym: Desvenlafaxine fumarate
IUPAC/Chemical Name: Phenol, 4-(2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)-, (2E)-2-butenedioate (1:1) (salt)
InChi Key: SQTJDJZCPOSWSC-WLHGVMLRSA-N
InChi Code: InChI=1S/C16H25NO2.C4H4O4/c1-17(2)12-15(13-6-8-14(18)9-7-13)16(19)10-4-3-5-11-16;5-3(6)1-2-4(7)8/h6-9,15,18-19H,3-5,10-12H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+
SMILES Code: CN(C)CC(c1ccc(O)cc1)C2(O)CCCCC2.OC(=O)\C=C\C(=O)O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 379.45 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Naseeruddin R, Rosani A, Marwaha R. Desvenlafaxine. 2020 Nov 29. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021 Jan–. PMID: 30521250.
2: Weihs KL, Murphy W, Abbas R, Chiles D, England RD, Ramaker S, Wajsbrot DB. Desvenlafaxine Versus Placebo in a Fluoxetine-Referenced Study of Children and Adolescents with Major Depressive Disorder. J Child Adolesc Psychopharmacol. 2018 Feb;28(1):36-46. doi: 10.1089/cap.2017.0100. Epub 2017 Nov 30. PMID: 29189044; PMCID: PMC5771543.
3: Alcantara-Montero A. Desvenlafaxina y dolor neuropatico: beneficios clinicos adicionales de un inhibidor de la recaptacion de serotonina-noradrenalina de segunda generacion [Desvenlafaxine and neuropathic pain: additional clinical benefits of a second generation serotonin-noradrenaline reuptake inhibitor]. Rev Neurol. 2017 Mar 1;64(5):219-226. Spanish. PMID: 28229443.
4: Drugs and Lactation Database (LactMed) [Internet]. Bethesda (MD): National Library of Medicine (US); 2006–. Desvenlafaxine. 2020 Oct 19. PMID: 30000652.
5: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012–. Venlafaxine, Desvenlafaxine. 2020 Mar 6. PMID: 31644106.
6: Poitras V, Visintini S. Desvenlafaxine versus Venlafaxine for the Treatment of Adult Patients with Major Depressive Disorder: A Review of the Comparative Clinical and Cost-Effectiveness [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2017 Oct 25. PMID: 29889482.
7: Yang LP, Plosker GL. Desvenlafaxine extended release. CNS Drugs. 2008;22(12):1061-9. doi: 10.2165/0023210-200822120-00008. PMID: 18998743.
8: Low Y, Setia S, Lima G. Drug-drug interactions involving antidepressants: focus on desvenlafaxine. Neuropsychiatr Dis Treat. 2018 Feb 19;14:567-580. doi: 10.2147/NDT.S157708. PMID: 29497300; PMCID: PMC5822840.
9: Laoutidis ZG, Kioulos KT. Desvenlafaxine for the acute treatment of depression: a systematic review and meta-analysis. Pharmacopsychiatry. 2015 Sep;48(6):187-99. doi: 10.1055/s-0035-1555879. Epub 2015 Jul 23. PMID: 26205685.
10: Sproule BA, Hazra M, Pollock BG. Desvenlafaxine succinate for major depressive disorder. Drugs Today (Barc). 2008 Jul;44(7):475-87. doi: 10.1358/dot.2008.44.7.1227147. PMID: 18806899.
