WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H413734
CAS#: 561-77-3 (free base)
Description: Dihexyverine Free Base is an antimuscarinic pharmaceutical drug related to dicycloverine used as a spasmolytic.
Hodoodo Cat#: H413734
Name: Dihexyverine Free Base
CAS#: 561-77-3 (free base)
Chemical Formula: C20H35NO2
Exact Mass: 321.27
Molecular Weight: 321.510
Elemental Analysis: C, 74.72; H, 10.97; N, 4.36; O, 9.95
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Related CAS #: 561-77-3 (free base) 5588-25-0 (HCl)
Synonym: Dihexyverine Free Base; BRN0247822; BRN-0247822; BRN 0247822
IUPAC/Chemical Name: (Bicyclohexyl)-1-carboxylic acid, 2-piperidinoethyl ester
InChi Key: MNSQDVCVWNXBFQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H35NO2/c22-19(23-17-16-21-14-8-3-9-15-21)20(12-6-2-7-13-20)18-10-4-1-5-11-18/h18H,1-17H2
SMILES Code: O=C(C1(C2CCCCC2)CCCCC1)OCCN3CCCCC3
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 321.51 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: FERRON M. [Preliminary clinical study on the use of dihexyverine in obstetrics]. Can Med Assoc J. 1962 Nov 24;87(21):1121-3. PMID: 13944939; PMCID: PMC1849825.
2: MEUNIER H. Sur l'emploi de la dihexyverine en gynécologie [Use of dihexyverine in gynecology]. Gaz Med Fr. 1957 Sep 25;64(18):1533-4. French. PMID: 13480436.
3: ROLLIN G. Essai de traitement des toux spasmodiques par un nouvel antispasmodique de synthèse: la dihexyverine [Trial therapy of spastic cough with a new synthetic antispasmodic: dihexyverine]. Gaz Med Fr. 1955 Dec 25;62(24):1962-3. French. PMID: 13294387.
4: DELECOUR, VITSE, MONNIER. [Clinical experimentation with an antispasmodic, "Dihexyverine", in obstetrical practice]. Lille Med. 1962 Feb;7:143-6. French. PMID: 13885120.
5: FRANCK C, GRANDPIERRE R. Action du dihexyvérine sur le bronchospasme histaminique chez le cobaye [Effect of dihexyverine on histaminic bronchospasm in guinea pigs]. Rev Pathol Gen Physiol Clin. 1955 Mar;55(666):387-9. French. PMID: 14396051.
6: SIMON C, CARRAUD G. Contribution au traitement des entéropathies; a propos des applications digestives d'un nouveau spasmolytique de synthèse: dihexyvérine [Contribution to the treatment of enteropathies; digestive application of a new synthetic spasmolytic--dihexyverine]. Sem Hop. 1955 Mar 20;31(18/2):91-3. French. PMID: 14373023.
7: FRANCOIS A. Des indications obstétricales prénatales de la dihexyvérine [Prenatal obstetric indications for dihexyverine]. Sem Hop. 1955 Sep 30;31(57):2980-3. French. PMID: 13267510.
8: FERRON M. [Preliminary clinical study on the use of dihexyverine in obstetrics]. Union Med Can. 1962 Aug;91:832-6. French. PMID: 13892604.
9: BILWEIS J. Etude expérimentale sur l'utilisation de la dihexyverine au cours du travail obstétrical dirigé selon la méthode d'accouchement physiologiquement accéléré [Experimental study on the use of dihexyverine in obstetrical labor by the physiological accelerated labor method]. Concours Med. 1958 Mar 8;80(10):1193-5. French. PMID: 13511938.
10: FRANCK C, LAMARCHE M, ROZE P. Modifications de la résistance au déficit en oxygène chez le cobaye après administration de dihexyvérine [Modifications in the resistance to oxygen deficiency in the guinea pig after administration of dihexyverine]. C R Seances Soc Biol Fil. 1955 Dec;149(23-24):2201-2. French. PMID: 13317334.
