WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H414110
CAS#: 77-15-6 (free base)
Description: Ethoheptazine Free Base is an opioid analgesic from the phenazepane family. It was invented in the 1950s and is a ring expanded analogue of pethidine. Ethoheptazine produces similar effects to other opioids, including analgesia, sedation, dizziness and nausea.
Hodoodo Cat#: H414110
Name: Ethoheptazine Free Base
CAS#: 77-15-6 (free base)
Chemical Formula: C16H23NO2
Exact Mass: 261.17
Molecular Weight: 261.370
Elemental Analysis: C, 73.53; H, 8.87; N, 5.36; O, 12.24
This product is not in stock, which may be available by custom synthesis.
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Related CAS #: 77-15-6 (free base) 6700-56-7 (citrate)
Synonym: Ethoheptazine Free Base; HSDB3326; HSDB-3326; HSDB 3326
IUPAC/Chemical Name: Azepine-4-carboxylic acid, hexahydro-1-methyl-4-phenyl-, ethyl ester
InChi Key: WGJHHMKQBWSQIY-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H23NO2/c1-3-19-15(18)16(14-8-5-4-6-9-14)10-7-12-17(2)13-11-16/h4-6,8-9H,3,7,10-13H2,1-2H3
SMILES Code: O=C(C1(C2=CC=CC=C2)CCN(C)CCC1)OCC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 261.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Sinclair JG. Ethoheptazine-monoamine oxidase inhibitor interaction in rabbits. Can J Physiol Pharmacol. 1972 Sep;50(9):923-6. doi: 10.1139/y72-132. PMID: 4678166.
2: Leander JD. Effects of propoxyphene, ethoheptazine, and azabicyclane on schedule-controlled responding: attenuation by pentobarbital but not naloxone. Psychopharmacology (Berl). 1979;66(1):19-22. doi: 10.1007/BF00431983. PMID: 44372.
3: Scheiner JJ, Richards DJ. Treatment of musculoskeletal pain and associated anxiety with an ethoheptazine-aspirin-meprobamate combination (equagesic): a controlled study. Curr Ther Res Clin Exp. 1974 Sep;16(9):928-36. PMID: 4214668.
4: Sweetman BJ, Baig A, Parsons DL. Mefenamic acid, chlormezanone-paracetamol, ethoheptazine-aspirin-meprobamate: a comparative study in acute low back pain. Br J Clin Pract. 1987 Feb;41(2):619-24. PMID: 2960369.
5: HAYNES CE, MORRISON RD. Clinical comparison of ethoheptazine and aspirin with other analgesic combinations. J Oral Surg Anesth Hosp Dent Serv. 1961 Mar;19:114-21. PMID: 13712506.
6: CASS LJ, FREDERIK WS, BARTHOLOMAY AF. Methods in evaluating ethoheptazine and ethoheptazine combined with aspirin. J Am Med Assoc. 1958 Apr 12;166(15):1829-33. doi: 10.1001/jama.1958.02990150025006. PMID: 13525157.
7: Lamphier T, Rodriguez A, Richards D. Double-blind study of the analgesic effect of ethoheptazine-aspirin. Curr Ther Res Clin Exp. 1974 Jul;16(7):718-33. PMID: 4210461.
8: Overton DA, Batta SK. Investigation of narcotics and antitussives using drug discrimination techniques. J Pharmacol Exp Ther. 1979 Nov;211(2):401-8. PMID: 41087.
9: ALBERTSON GL. Clinical investigation of ethoheptazine citrate and acetylsalicylic acid as a postoperative analgesic in oral surgery. Oral Surg Oral Med Oral Pathol. 1959 Apr;12(4):438-41. doi: 10.1016/0030-4220(59)90055-6. PMID: 13644904.
10: Winter L Jr, Calman HI, Caruso WA, Post A. A double-blind comparison of ethoheptazine citrate, propoxyphene hydrochloride, and placebo. Curr Ther Res Clin Exp. 1973 Jul;15(7):383-90. PMID: 4198299.
