WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H577080
CAS#: 64003-26-5 (mesylate)
Description: Mefloquine mesylate is a phospholipid-interacting antimalarial drug.
Hodoodo Cat#: H577080
Name: Mefloquine mesylate
CAS#: 64003-26-5 (mesylate)
Chemical Formula: C18H20F6N2O4S
Exact Mass: 474.10
Molecular Weight: 474.420
Elemental Analysis: C, 45.57; H, 4.25; F, 24.03; N, 5.90; O, 13.49; S, 6.76
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Related CAS #: 51773-92-3 (HCl) 53230-10-7 (free base) 64003-26-5 (mesylate)
Synonym: Mefloquine mesylate; Mefloquine methanesulfonate
IUPAC/Chemical Name: 4-Quinolinemethanol, alpha-2-piperidinyl-2,8-bis(trifluoromethyl)-, (R*,s*)-(+/-)-, monomethanesulfonate (salt)
InChi Key: GFKKBAFIZVIFAZ-YLCXCWDSSA-N
InChi Code: InChI=1S/C17H16F6N2O.CH4O3S/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11;1-5(2,3)4/h3-5,8,12,15,24,26H,1-2,6-7H2;1H3,(H,2,3,4)/t12-,15+;/m1./s1
SMILES Code: CS(=O)(=O)O.O[C@H]([C@H]1CCCCN1)c2cc(nc3c(cccc23)C(F)(F)F)C(F)(F)F
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 474.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Goto TE, Caseli L. The interaction of mefloquine hydrochloride with cell membrane models at the air-water interface is modulated by the monolayer lipid composition. J Colloid Interface Sci. 2014 Oct 1;431:24-30. doi: 10.1016/j.jcis.2014.05.050. Epub 2014 Jun 14. PubMed PMID: 24980622.
2: Yadav AV, Dabke AP, Shete AS. Crystal engineering to improve physicochemical properties of mefloquine hydrochloride. Drug Dev Ind Pharm. 2010 Sep;36(9):1036-45. doi: 10.3109/03639041003642065. PubMed PMID: 20334542.
3: Karle JM, Karle IL. Crystal structure of (-)-mefloquine hydrochloride reveals consistency of configuration with biological activity. Antimicrob Agents Chemother. 2002 May;46(5):1529-34. PubMed PMID: 11959592; PubMed Central PMCID: PMC127198.
4: Stockwell JR. Aeromedical considerations of malaria prophylaxis with mefloquine hydrochloride. Aviat Space Environ Med. 1982 Oct;53(10):1011-3. PubMed PMID: 6983345.