WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H465306
CAS#: 1208222-39-2
Description: VU0365114 is a positive allosteric modulator of M5 muscarinic acetylcholine receptors (mAChRs). It increases ACh-induced calcium mobilization in CHO cells expressing human M5 mAChRs (EC50 = 2.7 µM) selectively over CHO cells expressing human M1-4 mAChRs (EC50s = >30 µM for all).
Hodoodo Cat#: H465306
Name: VU0365114
CAS#: 1208222-39-2
Chemical Formula: C22H14F3NO3
Exact Mass: 397.09
Molecular Weight: 397.353
Elemental Analysis: C, 66.50; H, 3.55; F, 14.34; N, 3.53; O, 12.08
Synonym: VU0365114; VU 0365114; VU-0365114;
IUPAC/Chemical Name: 1-([1,1'-biphenyl]-4-ylmethyl)-5-(trifluoromethoxy)indoline-2,3-dione
InChi Key: SPBGRXOPAXZSER-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H14F3NO3/c23-22(24,25)29-17-10-11-19-18(12-17)20(27)21(28)26(19)13-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-12H,13H2
SMILES Code: O=C1C(N(C2=CC=C(OC(F)(F)F)C=C12)CC3=CC=C(C=C3)C4=CC=CC=C4)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
Solvent | Max Conc. mg/mL | Max Conc. mM | |
---|---|---|---|
Solubility | |||
Ethanol | 10.0 | 25.17 | |
DMSO | 30.0 | 75.50 | |
DMF | 30.0 | 75.50 |
The following data is based on the product molecular weight 397.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |