WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H465424
CAS#: 1322645-32-8 (free base)
Description: VGD020 is a CD4 and sortilin inhibitor. It displayed activity for sortilin down-modulation and reduction of progranulin-induced breast cancer stem cell propagation.
Hodoodo Cat#: H465424
Name: VGD020
CAS#: 1322645-32-8 (free base)
Chemical Formula: C31H45N3O5S2
Exact Mass: 603.28
Molecular Weight: 603.837
Elemental Analysis: C, 61.66; H, 7.51; N, 6.96; O, 13.25; S, 10.62
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Related CAS #: 1322645-32-8 (free base) 1322646-07-0 (HCl)
Synonym: VGD020; VGD 020; VGD-020;
IUPAC/Chemical Name: 9-(cyclohexylmethyl)-1-((4-methoxyphenyl)sulfonyl)-3-methylene-5-tosyl-1,5,9-triazacyclododecane
InChi Key: IADINMLQCKJBSG-UHFFFAOYSA-N
InChi Code: InChI=1S/C31H45N3O5S2/c1-26-11-15-30(16-12-26)40(35,36)33-21-7-19-32(25-28-9-5-4-6-10-28)20-8-22-34(24-27(2)23-33)41(37,38)31-17-13-29(39-3)14-18-31/h11-18,28H,2,4-10,19-25H2,1,3H3
SMILES Code: C=C1CN(S(=O)(C2=CC=C(C)C=C2)=O)CCCN(CCCN(S(=O)(C3=CC=C(OC)C=C3)=O)C1)CC4CCCCC4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 603.84 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Berger K, Pauwels E, Parkinson G, Landberg G, Le T, Demillo VG, Lumangtad LA, Jones DE, Islam MA, Olsen R, Kapri T, Intasiri A, Vermeire K, Rhost S, Bell TW. Reduction of Progranulin-Induced Breast Cancer Stem Cell Propagation by Sortilin-Targeting Cyclotriazadisulfonamide (CADA) Compounds. J Med Chem. 2021 Aug 24. doi: 10.1021/acs.jmedchem.1c00943. Epub ahead of print. PMID: 34428050.
2: Ali R, Anugu S, Chawla R, Demillo VG, Goulinet-Mateo F, Gyawali S, Hamal S, Jones DE, Lamprecht K, Le T, Lumangtad LA, Pflug NC, Sama A, Scarbrough ED, Bell TW. Tsuji-Trost Cyclization of Disulfonamides: Synthesis of 12-Membered, 11-Membered, and Pyridine-Fused Macrocyclic Triamines. ACS Omega. 2019 Jan 31;4(1):1254-1264. doi: 10.1021/acsomega.8b02555. Epub 2019 Jan 15. PMID: 30729225; PMCID: PMC6356871.
3: Demillo VG, Goulinet-Mateo F, Kim J, Schols D, Vermeire K, Bell TW. Unsymmetrical cyclotriazadisulfonamide (CADA) compounds as human CD4 receptor down-modulating agents. J Med Chem. 2011 Aug 25;54(16):5712-21. doi: 10.1021/jm2002603. Epub 2011 Jul 29. PMID: 21800875.