WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H577494
CAS#: 87691-92-7 (HCl)
Description: Tiospirone hydrochloride is an atypical antipsychotic drug.
Hodoodo Cat#: H577494
Name: Tiospirone hydrochloride
CAS#: 87691-92-7 (HCl)
Chemical Formula: C24H33ClN4O2S
Exact Mass: 476.20
Molecular Weight: 477.060
Elemental Analysis: C, 60.42; H, 6.97; Cl, 7.43; N, 11.74; O, 6.71; S, 6.72
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Related CAS #: 87691-92-7 (HCl) 87691-91-6 (free base)
Synonym: BMY-13,859; MJ 13859-1; Tiospirone hydrochloride; Tiospirone HCl
IUPAC/Chemical Name: 8-Azaspiro(4.5)decane-7,9-dione, 8-(4-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)butyl)-, monohydrochloride
InChi Key: RYAWYTKDKQCORF-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H32N4O2S.ClH/c29-21-17-24(9-3-4-10-24)18-22(30)28(21)12-6-5-11-26-13-15-27(16-14-26)23-19-7-1-2-8-20(19)31-25-23;/h1-2,7-8H,3-6,9-18H2;1H
SMILES Code: Cl.O=C1CC2(CCCC2)CC(=O)N1CCCCN3CCN(CC3)c4nsc5ccccc45
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 477.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1. Arolfo MP, McMillen BA. Tiospirone and the reinforcing effects of cocaine in the conditioned place preference paradigm in rats. J Pharm Pharmacol. 2000 Aug;52(8):977-81. doi: 10.1211/0022357001774697. PMID: 11007069.
2. Arolfo MP, McMillen BA. Effects of amperozide and tiospirone, atypical antipsychotic 5-HT2 drugs, on food-reinforced behavior in rats. Physiol Behav. 1999 Dec 1-15;68(1-2):93-8. doi: 10.1016/s0031-9384(99)00141-9. PMID: 10627067.