WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H465812
CAS#: 2639330-26-8 (free base)
Description: ZB-S-29 is a highly efficient SHP2 degrader with a DC50 of 6.02 nM. ZB-S-29 effectively induced the degradation of SHP2 protein in a time and dose-dependent manner with a DC50 of 6.02 nM in MV4;11 cells, and induced more than 90% SHP2 degradation at 500 nM after 24 h of treatment. Moreover, it exhibited significant cell proliferation inhibition in MV4;11 cells and induced apparent G1 phase arrest or apoptosis in a dose-dependent manner.
Hodoodo Cat#: H465812
Name: ZB-S-29
CAS#: 2639330-26-8 (free base)
Chemical Formula: C46H59ClN10O10S
Exact Mass: 978.38
Molecular Weight: 979.548
Elemental Analysis: C, 56.40; H, 6.07; Cl, 3.62; N, 14.30; O, 16.33; S, 3.27
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Related CAS #: 2639330-26-8 (free base) 2648285-15-6 (TFA),
Synonym: ZB-S-29; ZBS-29; ZB S-29; ZB-S29; ZB-S 29; ZBS29; ZB S 29;
IUPAC/Chemical Name: N1-(3-((3-amino-5-((3S,4S)-4-amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl)pyrazin-2-yl)thio)-2-chlorophenyl)-N4-(3-(2-(2-(3-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)amino)propoxy)ethoxy)ethoxy)propyl)succinamide
InChi Key: GOEFYTZABOPTQD-PXUBBKKOSA-N
InChi Code: InChI=1S/C46H59ClN10O10S/c1-28-40(48)46(27-67-28)14-18-56(19-15-46)34-26-52-43(41(49)54-34)68-33-9-3-8-31(39(33)47)53-36(59)13-12-35(58)51-17-5-21-65-23-25-66-24-22-64-20-4-16-50-30-7-2-6-29-38(30)45(63)57(44(29)62)32-10-11-37(60)55-42(32)61/h2-3,6-9,26,28,32,40,50H,4-5,10-25,27,48H2,1H3,(H2,49,54)(H,51,58)(H,53,59)(H,55,60,61)/t28-,32?,40+/m0/s1
SMILES Code: NC1=C(SC2=CC=CC(NC(CCC(NCCCOCCOCCOCCCNC3=CC=CC(C(N4C5C(NC(CC5)=O)=O)=O)=C3C4=O)=O)=O)=C2Cl)N=CC(N6CCC7([C@H](N)[C@H](C)OC7)CC6)=N1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 979.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
