ETX0462

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H466025

CAS#: 2233569-54-3 (free acid)

Description: ETX0462 is the first novel Gram-negative chemotype to treat life-threatening antibiotic-resistant infections, showing potent in vitro and in vivo activity against Pseudomonas aeruginosa plus all other Gram-negative ESKAPE pathogens, Stenotrophomonas maltophilia and biothreat pathogens.

Chemical Structure

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ETX0462
CAS# 2233569-54-3 (free acid)
Instruction

Theoretical Analysis

Hodoodo Cat#: H466025
Name: ETX0462
CAS#: 2233569-54-3 (free acid)
Chemical Formula: C10H13N6NaO6S
Exact Mass: 368.05
Molecular Weight: 368.300
Elemental Analysis: C, 32.61; H, 3.56; N, 22.82; Na, 6.24; O, 26.06; S, 8.70

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 2233569-54-3 (free acid)    

Synonym: ETX0462; ETX 0462; ETX-0462;

IUPAC/Chemical Name: sodium (4R,8S)-8-((E)-N-hydroxy-N'-methylcarbamimidoyl)-1-methyl-6-oxo-4,8-dihydro-1H-4,7-methanopyrazolo[3,4-e][1,3]diazepin-5(6H)-yl sulfate

InChi Key: DENRJGZATCJYJD-QMGYSKNISA-M

InChi Code: InChI=1S/C10H14N6O6S.Na/c1-11-9(13-18)8-7-5(3-12-14(7)2)6-4-15(8)10(17)16(6)22-23(19,20)21;/h3,6,8,18H,4H2,1-2H3,(H,11,13)(H,19,20,21);/q;+1/p-1/t6-,8-;/m0./s1

SMILES Code: O=S(ON1C(N2[C@H](/C(NO)=N\C)C(N(C)N=C3)=C3[C@]1([H])C2)=O)([O-])=O.[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: To be determined

Shelf Life: >2 years if stored properly

Drug Formulation: To be determined

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 368.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Durand-Reville TF, Miller AA, O'Donnell JP, Wu X, Sylvester MA, Guler S, Iyer R, Shapiro AB, Carter NM, Velez-Vega C, Moussa SH, McLeod SM, Chen A, Tanudra AM, Zhang J, Comita-Prevoir J, Romero JA, Huynh H, Ferguson AD, Horanyi PS, Mayclin SJ, Heine HS, Drusano GL, Cummings JE, Slayden RA, Tommasi RA. Rational design of a new antibiotic class for drug-resistant infections. Nature. 2021 Sep;597(7878):698-702. doi: 10.1038/s41586-021-03899-0. Epub 2021 Sep 15. PMID: 34526714.