WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H578096
CAS#: 1049743-58-9 (2HCl)
Description: PS-1145 is a selective IκB kinase (IKK) inhibitor (IC50 = 100 nM). PS1145 efficiently inhibited both basal and induced NF-kappaB activity in PC cells. PS1145 induced caspase 3/7-dependent apoptosis in PC cells and significantly sensitized PC cells to apoptosis induced by tumor necrosis factor alpha. PS1145 inhibited PC cell proliferation. PS1145 enhances apoptosis in DMBA-induced tumor in male Wistar rats. PS1145 can overcome imatinib resistance.
Hodoodo Cat#: H578096
Name: PS-1145 HCl
CAS#: 1049743-58-9 (2HCl)
Chemical Formula: C17H13Cl3N4O
Exact Mass: 394.02
Molecular Weight: 395.670
Elemental Analysis: C, 51.61; H, 3.31; Cl, 26.88; N, 14.16; O, 4.04
Related CAS #: 431898-65-6 (free base) 1049743-58-9 (2HCl)
Synonym: PS 1145 dihydrochloride; PS-1145 HCl, PS1145; PS 1145.
IUPAC/Chemical Name: N-(6-Chloro-9H-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide dihydrochloride
InChi Key: QTDCBADLGJZBHP-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H11ClN4O.2ClH/c18-11-6-13-12-3-5-20-9-15(12)21-16(13)14(7-11)22-17(23)10-2-1-4-19-8-10;;/h1-9,21H,(H,22,23);2*1H
SMILES Code: O=C(C1=CC=CN=C1)NC2=CC(Cl)=CC3=C2NC4=C3C=CN=C4.[H]Cl.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 395.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
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In vivo protocol: |