WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H112104
CAS#: 16891-85-3
Description: Roridin E inhibits the receptor tyrosine kinases FGFR3, IGF-1R, PDGFRβ, and TrkB (IC50s = 0.4, 0.4, 1.4, and 1 μM, respectively) and induces cytotoxicity in multiple breast cancer cell lines (IC50s = 0.02-0.05 nM). It also inhibits proliferation in a panel of additional cancer cell lines (IC50s = <0.01 μM).
Hodoodo Cat#: H112104
Name: Roridin E
CAS#: 16891-85-3
Chemical Formula: C29H38O8
Exact Mass: 514.26
Molecular Weight: 514.620
Elemental Analysis: C, 67.69; H, 7.44; O, 24.87
Synonym: Roridin E
IUPAC/Chemical Name: (2S,4'E,9'R,10'E,12'Z,16a'S,18'R,19a'R,23a'R)-9'-((R)-1-hydroxyethyl)-5',16a',21'-trimethyl-6',7',16',16a',19a',22'-hexahydro-1'H,3'H,18'H,23'H-spiro[oxirane-2,17'-[16,18]methano[1,6,12]trioxacyclooctadecino[3,4-d]chromene]-3',14'(9'H)-dione
InChi Key: KEEQQEKLEZRLDS-ZOHHDLAGSA-N
InChi Code: InChI=1S/C29H38O8/c1-18-9-11-28-16-34-26(32)14-19(2)10-12-33-21(20(3)30)7-5-6-8-25(31)37-22-15-24(36-23(28)13-18)29(17-35-29)27(22,28)4/h5-8,13-14,20-24,30H,9-12,15-17H2,1-4H3/b7-5+,8-6-,19-14+/t20-,21-,22?,23-,24-,27-,28-,29+/m1/s1
SMILES Code: CC1=C[C@@]2([C@]3(CC1)[C@@]4([C@]5([C@]([H])(O2)CC4OC(/C=C\C=C\[C@]([H])([C@@H](C)O)OCC/C(C)=C/C(OC3)=O)=O)OC5)C)[H]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: To be determined
Shelf Life: >2 years if stored properly
Drug Formulation: To be determined
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
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The following data is based on the product molecular weight 514.62 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |